IgM monoclonal gammopathy of undetermined significance

Patients with IgM MGUS lack the signs and symptoms of an overt lymphoproliferative disorder of plasma cell neoplasm, and the paraprotein is typically discovered incidentally on serum protein electrophoresis.

IgM MGUS

IgM monoclonal gammopathy of undetermined significance (MGUS) is defined by a serum IgM paraprotein concentration < 30 gram per liter; bone marrow lymphoplasmacytic infiltration of < 10%; and no evidence of anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, hepatosplenomegaly, or other end-organ damage that can be attributed to the underlying lymphoproliferative disorder.

IgM MGUS is a precursor condition that may progress to overt lymphoma, lymphoplasmacytic lymphoma (LPL), Waldenstrom macroglobulinemia, or primary amyloidosis.

273.1 Monoclonal paraproteinemia

D47.2 Monoclonal gammopathy

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 236

National Cancer Institute
Section: General Information About Plasma Cell Neoplasms
Pages: https://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577