SIMAL-second induction/maintenance

• Etoposide
• Teniposide
• Daunorubicin Hydrochloride
• Asparaginase
• Leucovorin
• Methotrexate
• Cytarabine
• Prednisone

Name

Etoposide

Alternate Names

Dom-Etoposide

Epipodophyllotoxin derivative

Epipodophyllotoxin ethylidene gluco-pyranoside

Eposine

Ethylidene-Lignan P

Etopophos

Podophyllotoxin derivative

Vepesid

VP 16-213

VP-16

VP-16213

Toposar

Abbreviations

EPEG

VP-16

VP-16-213

Category

Chemotherapy

Subcategory

Epipodophyllotoxin, topoisomerase II inhibitor

Plant alkaloid

NSC Number

141540

Primary Site

Gastric cancer

Hodgkins lymphoma

Lung cancer (NSCLC, SCLC)

Non-Hodgkin lymphoma

testicular cancer (Germ cell tumors)

Histology

None

Remarks

Plant alkaloid. FDA approved use on small-cell lung cancer, testicular cancer.

Coding

This drug should be coded

Name

Teniposide

Alternate Names

Epipodophyllotoxin

Thenylidene

Thenylidene-lignan-P

Vee M-26

Vehem

VM-26

Vumon

Abbreviations

EPT

PTG

Category

Chemotherapy

Subcategory

Topoisomerase inhibitor

NSC Number

122819

Primary Site

None

Histology

None

Remarks

Derivative of podophyllotoxin with antineoplastic activity; plant alkaloid. FDA approved use in pediatric refractory ALL.

Coding

This drug should be coded

Name

Daunorubicin Hydrochloride

Alternate Names

Acetyladriamycin

Cerubidine

Dauno-blastin

Daunomycin

Daunomycin-HCl

Daunorubicin

Daunorubicine

FI-6339

Leuk-aemomycin C

NDC-0082-4155

RP-13057

Rubidomycin

Rubidomycin HCl

Rubomycin C

Abbreviations

Daun

Dauno

DNM

DNR

DRB

Category

Chemotherapy

Subcategory

Antitumor antibiotic

NSC Number

082151

82151

Primary Site

Leukemia

Histology

None

Remarks

FDA approved use on ALL and ANLL; antitumor antibiotic

Coding

This drug should be coded

Name

Asparaginase

Alternate Names

Asnase

Asparaginase (Escherichia coli)

Colaspase

Crasnitin#

EC3.1.5.1.

Elspar

Kidrolase

L-Asparaginase

Leunase (enzyme)

MK-965

Re-82-TAD-15

Abbreviations

ASP

ASPA

L-ASE

L-ASP

Category

Chemotherapy

Subcategory

Antineoplastic agent

NSC Number

109229

Primary Site

Acute lymphoblastic leukemia (ALL)

Histology

None

Remarks

Antineoplastic.

Coding

This drug should be coded

Name

Leucovorin

Alternate Names

Calcium folinate

Calcium leucovorin

Calcium leucovorin rescue

Citrovorum Factor

Citrovorum factor rescue

Folic acid

Folinic Acid

Lederfoline

Leucosar

Leucovorin Calcium

Leucovorin rescue

Wellcovorin

Abbreviations

C.F.

CF

CL

Category

Ancillary Agent

Subcategory

None

NSC Number

3590

003590

Primary Site

None

Histology

None

Remarks

The pharmacologically active form of folic acid. FDA approved uses as 1st line colorectal carcinoma in combination with 5-FU and to diminish methotrexate toxicity.

Coding

This drug should NOT be coded

Name

Methotrexate

Alternate Names

Amethopterin

Antifolan

CL-14377

Folex

Methotrexate Sodium

Mexate

Mexate AQ

Rheumatrex

WR-19039

Abbreviations

MTX

Category

Chemotherapy

Subcategory

Antimetabolite

NSC Number

740

000740

Primary Site

Acute lymphoblastic leukemia (ALL)

Bladder cancer

Breast

Gestational trophoblastic cancer

head & neck cancer

lymphoma

Meningeal leukemia

Non-Hodgkin lymphoma

Osteogenic sarcoma

Primary CNS lymphoma

Histology

None

Remarks

FDA approved uses on ALL, breast cancer, choriocarcinoma, head and neck cancer, lymphoma, and osteosarcoma.

Coding

This drug should be coded

Name

Cytarabine

Alternate Names

AC-1075

Alexan

Ara-cytidine

Arabinocytidine

Arabinosylcytosine

Beta-Arabinosylcytosine

Cytarabin

Cytarabine

Cytarabinoside

Cytosar

Cytosar-U

Cytosine Arabinoside

Cytosine arabinoside hydrochloride

Spongocytidine HCL

Tarabine

Tarabine PFS

U-19920

U-19920A

WR-28453

Abbreviations

ara-C

CA

HDA

HDARA-C

Category

Chemotherapy

Subcategory

Antimetabolite

NSC Number

063878

63878

Primary Site

ALL

AML

CML

head and neck

Hodgkin's disease

leukemia

Meningeal leukemia

NHL

Histology

None

Remarks

Antineoplastic agent; antimetabolite. FDA approved uses on Hodgkin's disease, leukemia; under investigation for Rx of Progressive Multifocal Leukoencephalopathy (PML)

Coding

This drug should be coded

Name

Prednisone

Alternate Names

Alti-Prednisone

Alto-Pred

Ancortone

Apo-Prednisone

Colisone

Cortan

Dacortin

Delta-Dome#

Deltasone

Deltra

Fernisone Buffered

Keysone

Liquid Pred

Meticorten

Novo-Prednisone

Orasone

Panasol

Paracort#

Prednicen M

SK-Prednisone

Sterapred DS

Ultracorten

Winpred

Abbreviations

PDN

PRD

PRED

Category

Hormones and hormonal mechanisms

Subcategory

Glucocorticoid

NSC Number

10023

010023

Primary Site

Prednisone is used in regimens to treat multiple sites and histologies

Histology

None

Remarks

Code Prednisone when it is part of a drug regimen.

Do not code Prednisone when it is given to treat symptoms or as a single agent. In most cases when Prednisone is given by itself and not as part of a drug regimen, it does not affect the cancer and would not be coded as treatment.

Coding

Please see remarks for additional information