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SEER Inquiry System - Report
Produced: 01/07/2026 10:19 AM
Question 20031155
Inquiry Details
References:
#1: 2004 SEER Manual, C-559. Appendix C
#2: CAP Protocol, Prostate, 16. January 2005
Question:
Discussion:
Answer:
This answer was provided in the context of CSv1 coding guidelines. The response may not be used after your registry database has been converted to CSv2.For cases diagnosed 2004 and forward:
Presence or absence of perineural invasion does not affect pathologic extension. Most likely perineural invasion is still localized. It means that there is tumor found along the track of the nerves in the prostate. Where the nerves enter the prostate, the capsule is thinner than in other areas; thus pathologists make note of the potential for extracapsular extension.
The CAP Cancer Protocol for Prostate states that perineural invasion "has been associated with a high risk of extraprostatic extension...although the exact prognostic significance remains to be determined."
Based on the available information, code the case example to 023 [Involves both lobes].
History:
For cases diagnosed 1998-2003:
EOD Extension--Prostate: Presence or absence of perineural invasion does not affect EOD extension. Most likely perineural invasion is still localized. It means that there is tumor found along the track of the nerves in the prostate. Where the nerves enter the prostate, the capsule is thinner than in other areas; thus pathologists make note of the potential for extracapsular extension.
The CAP Cancer Protocol for Prostate states that perineural invasion "has been associated with a high risk of extraprostatic extension...although the exact prognostic significance remains to be determined."
Based on the available information, code the case example to extension 34 [Extending into prostatic apex]. The adenocarcinoma apparently involves the apex.
References: CAP Cancer Protocol, Prostate, Page 18, January 2003
SEER 1998 Manuals Errata, Page 4, February 1999
