SEER Inquiry System - Question 20081002 Details

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Produced: 04/15/2026 5:29 PM

Question 20081002

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Inquiry Details

References:

ICD-O-3

Question:

Primary site: What is the correct primary site code for angiosarcoma of the spleen with mets to bone marrow C42.2 vs C49x? See Discussion.

Discussion:

Robbins Pathology states the following about liver angiosarcomas: Hepatic angiosarcomas are rare but of interest because they are associated with distinct carcinogens, including arsenic (exposure to arsenical pesticides), Thorocast (a radioactive contrast medium previously widely used in radiology), and polyvinyl chloride (PVC) (widely used in plastics). The increased frequency of angiosarcomas among works in the PVC industry is one of the truly well-documented instances of chemical carcinogenesis in humans. With all these agents, there is a very long latent period of many years between exposure and the development of tumors.

Could the same apply to the spleen?

Answer:

Code C422 [Spleen] as the primary site for angiosarcoma of spleen with metastasis to bone marrow.

Cancer Site Category:

N/A

Data Item Category:

Primary site

Other Category:

N/A

Year:

2008