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SEER Inquiry System - Report
Produced: 09/16/2026 1:03 AM
Question 20110056
Inquiry Details
References:
Heme & Lymph Manual & DB
Question:
Discussion:
Answer:
Updated May 2026
Per the Heme DB, PTLD commonly involves lymph nodes, GI tract, lungs, and liver. Although CNS involvement is rare, in solid organ recipients the CNS may be the only site of involvement or may be associated with multi-organ involvement. Code the primary site to C719 [brain, NOS] and the histology to 9971/3 [post-transplant lymphoproliferative disorder (PTLD)]
History:
This SINQ question has been updated to the Hematopoietic & Lymphoid Neoplasm Manual & Database published January 2014.
The original answer below was written based on the rules in 2010
For cases diagnosed 2010-2011, access the Hematopoietic Database at http://seer.cancer.gov/tools/heme/. Click on Hematopoietic Project. Click on Hematopoietic and Lymphoid Database. For 2010-2011 diagnoses, click on the "use the 2010 database" label in the upper right corner of the screen. The 2010 Hematopoietic Coding Manual (PDF) button will appear to indicate the correct version of the program is available now for query.
Post-transplant lymphoproliferative disorder (PTLD) can be coded to the brain. When in doubt about a primary site code, refer to the Heme DB Abstractor Notes for help. The steps used to arrive at this decision are:
Enter in the Heme DB to find the histology. Click on the SEARCH button. The term "polymorphic post-transplant lymphoproliferative disorder (PTLD)" [9971/3] is highlighted.
Scroll to the ABSTRACTOR NOTE section. Per the notes, PTLD commonly involves lymph nodes, GI tract, lungs, and liver. Although CNS involvement is rare, in solid organ recipients the CNS may be the only site of involvement or may be associated with multi-organ involvement.
