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SEER Inquiry System - Report
Produced: 12/14/2025 12:53 PM
Question 20240032
Inquiry Details
References:
#1: 2007 Solid Tumor Rules. Other Sites, 2024 Update
#2: WHO Class Digest System Tumors, 273-275. 5th edition
Question:
Update to Current Manual/Reportability--Biliary Tract, Gallbladder: Is a diagnosis of high grade dysplasia of the gallbladder reportable? See Discussion.
Discussion:
Patient was diagnosed March 2024 with high grade dysplasia of the gallbladder during excision for clinical history of acute cholecystitis and obstruction.
Per the STR, Table 10 for Gallbladder and Extrahepatic Bile Duct Histologies shows Biliary intraepithelial neoplasia, high grade as code 8148/2. High grade glandular intraepithelial neoplasia of the biliary tract is also code 8148/2.
Recent SINQ 20240021 (GI specific) indicates high grade dysplasia is reportable as high grade glandular intraepithelial neoplasia (8148/2) for stomach, small intestine, and esophagus. Does the same hold true for gallbladder? If so, then it appears there is a conflict between STR and Appendix E2.
However, using the logic of SINQ 20240021 for this site would appear to contradict Appendix E2 which indicates high grade dysplasia in sites other than stomach, intestine, and esophageal sites is not reportable.
If we can code high grade dysplasia of GI sites to 8148/2, should we accession high grade dysplasia of the gallbladder and other biliary sites in a similar manner? If so, then Appendix E needs to be modified.
Answer:
Report biliary intraepithelial neoplasia (dysplasia), high grade. As noted in SINQ 20240021 and the Other Sites Solid Tumor Rules, Rules H4/H26, the listed sites may not include all reportable neoplasms for 8148/2.
We will update the Other Sites Solid Tumor Rules to reflect this code as well as make revisions in the next release of the SEER Manual.
