Lymphocyte-depleted classical Hodgkin lymphoma

Lymphocyte-depleted classical Hodgkin lymphoma
ICD-O-1 Morphology
9653/3: Hodgkin lymphoma, lymphocytic depletion, NOS
Effective 1978 - 1991
ICD-O-2 Morphology
9653/3: Hodgkin lymphoma, lymphocytic depletion, NOS
Effective 1992 - 2000
ICD-O-3 Morphology
9653/3: Hodgkin lymphoma, lymphocytic depletion, NOS
Effective 2001 and later
for cases diagnosed 1978 and later
Primary Site(s)
See Module 7. Lymph nodes (C770-C779) are the usual primary sites; however, involvement in other sites is possible. If you have confirmation that the only involved site is something other than lymph nodes, then code to that primary site.

Code grade specified by pathologist. If no grade specified, code 9
Module Rule
Alternate Names
Classical Hodgkin lymphoma, lymphocyte depletion, NOS
Most uncommon subtype of Hodgkin lymphoma. Variable morphology, consistent relative predominance of Reed-Sternberg cells and variants with depletion of non-neoplastic lymphocytes. Fibrotic and reticular/sarcomatous subtypes.
Abstractor Notes
Lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) has a predilection for retroperitoneal lymph nodes, abdominal organs, and bone marrow. Compared to other subtypes of CHL, LDCHL presents at a more advanced stage (III-IV) and with B symptoms.

Prior to modern therapy the course of LDCHL was aggressive and it has remained so in some parts of Europe and developing countries.

Per WHO, Hodgkin lymphomas are primarily B-cell lymphomas. If the medical record states B-cell, code 6. Since there are Hodgkin lymphomas that are not B-cell, the default grade is 9 (unknown) where the documentation does not specifically state B-cell.

For more information on this neoplasm, see the NCI website: or
Definitive Diagnostic Methods
Histologic confirmation
Genetics Data
EBV positive cases stain positively for LMP
Hormone therapy
Radiation therapy
Corresponding ICD-9 Codes
201.7 Hodgkin's disease, lymphocytic depletion
Corresponding ICD-10 Codes
C81.3 Hodgkin's disease, lymphocytic depletion
Corresponding ICD-10-CM Codes (U.S. only)
C81.3 Lymphocyte depleted classical Hodgkin lymphoma (effective October 01, 2015)
Signs and Symptoms
Drenching night sweats
Fever (for no known reason)
Pain in the chest, abdomen, or bones (for no known reason)
Painless swelling in the lymph nodes
Skin rash or itchy skin
Weight loss (for no known reason)
Diagnostic Exams
Progression and Transformation
Epidemiology and Mortality
Age: 30-37 years median age
Incidence: <1% of classical Hodgkin lymphomas
Sex: male predominance