ICD-O-1 Morphology

Effective 1978 - 1991

ICD-O-2 Morphology

Effective 1992 - 2000

ICD-O-3 Morphology

9655/3: Hodgkin lymphoma, lymphocyte depletion, reticular
Effective 2001 and later

Reportable

for cases diagnosed 1978 and later

Primary Site(s)

C770-C779
Lymph nodes (C770-C779) are the usual primary sites; however, involvement in other sites is possible. If you have confirmation that the only involved site is something other than the lymph nodes, than code to that primary site. See Module 7.

Grade

Not Applicable

Module Rule

None

Alternate Names

Classical Hodgkin lymphoma, lymphocyte depletion, reticular

Definition

Hodgkin lymphoma, lymphocyte depletion, reticular is a subtype of Hodgkin lymphoma lymphocyte depletion, characterized by extremely large numbers of Hodgkin and Reed-Sternberg cells, some of which appear to be mummified. Diffuse effacement of normal lymph node structure; small lymphocytes, plasma cells, histiocytes, granulocytes are scanty. Foci of necrosis usually encountered.

Abstractor Notes

Hodgkin lymphoma, lymphocyte depletion includes diffuse fibrosis and reticular Hodgkin's disease from the Lukes and Butler classification. This neoplasm is now very rarely diagnosed, and it is recognized that many cases previously diagnosed as HD (lymphocyte-depletion) are in fact examples of non-Hodgkin's lymphoma, commonly of anaplastic large cell type Anaplastic Large Cell Lymphoma. The majority of cases of show morphological features of diffuse fibrosis characterized by a hypocellular background containing bizarre H-RS cells and associated with non-collagenous fibrosis.

This code should be used only for historic cases unless no other diagnosis is available.

Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.

Definitive Diagnostic Methods

Histologic confirmation

Genetics Data

None

Immunophenotyping

None

Treatments

Chemotherapy
Hormone therapy
Radiation therapy

Transformations to

None

Corresponding ICD-9 Codes

201.7 Hodgkin's disease, lymphocytic depletion

Corresponding ICD-10 Codes

C81.3 Hodgkin's disease, lymphocytic depletion

Corresponding ICD-10-CM Codes (U.S. only)

C81.3 Lymphocyte depleted classical Hodgkin lymphoma (effective October 01, 2015)

Signs and Symptoms

Drenching night sweats
Pain the chest, abdomen, or bones (for no known reason)
Painless swelling in the lymph nodes in the neck, underarm, groin, or stomach
Skin rash or itchy skin
Weight loss (for no known reason)

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

International Classification of Diseases for Oncology, Third Edition, First Revision. Geneva: World Health Organization, 2013.
Section: ICD-O-3.1 (2011) Morphological Codes
Pages: http://codes.iarc.fr/codegroup/2

National Cancer Institute
Section: General Information About Adult Hodgkin Lymphoma (HL)
Pages: https://www.cancer.gov/types/lymphoma/hp/adult-hodgkin-treatment-pdq
Glossary