Hodgkin lymphoma, lymphocyte depletion, reticular

ICD-O-1 Morphology

Effective 1978 - 1991

ICD-O-2 Morphology

Effective 1992 - 2000

ICD-O-3 Morphology

9655/3: Hodgkin lymphoma, lymphocyte depletion, reticular
Effective 2001 and later


for cases diagnosed 1978 and later

Primary Site(s)

Lymph nodes (C770-C779) are the usual primary sites; however, involvement in other sites is possible. If you have confirmation that the only involved site is something other than the lymph nodes, than code to that primary site. See Module 7.

Abstractor Notes

Hodgkin lymphoma, lymphocyte depletion includes diffuse fibrosis and reticular Hodgkin's disease from the Lukes and Butler classification. This neoplasm is now very rarely diagnosed, and it is recognized that many cases previously diagnosed as HD (lymphocyte-depletion) are in fact examples of non-Hodgkin's lymphoma, commonly of anaplastic large cell type Anaplastic Large Cell Lymphoma. The majority of cases of show morphological features of diffuse fibrosis characterized by a hypocellular background containing bizarre H-RS cells and associated with non-collagenous fibrosis.

This code should be used only for historic cases unless no other diagnosis is available.

Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.

Diagnostic Confirmation

This is a histology for which the Definitive Diagnostic Method does not include Genetics Data or Immunophenotyping, thus Diagnostic Confirmation should never be 3. If genetics and/or immunophenotyping are available, re-review to see if a more specific neoplasm can be coded.


Not Applicable

Module Rule


Alternate Names

Classical Hodgkin lymphoma, lymphocyte depletion, reticular


Hodgkin lymphoma, lymphocyte depletion, reticular is a subtype of Hodgkin lymphoma lymphocyte depletion, characterized by extremely large numbers of Hodgkin and Reed-Sternberg cells, some of which appear to be mummified. Diffuse effacement of normal lymph node structure; small lymphocytes, plasma cells, histiocytes, granulocytes are scanty. Foci of necrosis usually encountered.

Definitive Diagnostic Methods

Histologic confirmation

Genetics Data





Hormone therapy
Radiation therapy

Transformations to


Corresponding ICD-9 Codes

201.7 Hodgkin's disease, lymphocytic depletion

Corresponding ICD-10 Codes

C81.3 Hodgkin lymphocytic depletion

Corresponding ICD-10-CM Codes (U.S. only)

C81.3 Lymphocyte depleted Hodgkin lymphoma (effective October 01, 2015)

Signs and Symptoms

Drenching night sweats
Pain the chest, abdomen, or bones (for no known reason)
Painless swelling in the lymph nodes in the neck, underarm, groin, or stomach
Peripheral lymphadenopathy
Skin rash or itchy skin
Weight loss (for no known reason)

Diagnostic Exams

Blood chemistry studies
CT (CAT) scan
Complete blood count
Erythrocyte sedimentation rate
Lymph node biopsy
PET (positron emission tomography) scan

Progression and Transformation


Epidemiology and Mortality



International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes

National Cancer Institute
Section: General Information About Adult Hodgkin Lymphoma (HL)