Search Database ICD-O-3 Code Lists

Name

Hodgkin lymphoma, lymphocyte depletion, reticular [OBS]

ICD-O-3 Morphology

9655/3: Hodgkin lymphoma, lymphocyte depletion, reticular
Effective 2001 and later

Reportable

for cases diagnosed 1978 and later

Primary Site(s)

C770-C779
Lymph nodes are the most common primary sites.
Common metastatic sites include the bone, CNS, liver, lung, and bone marrow.
Spleen involvement is common due to dissemination of disease

Assign C779 if specific primary site cannot be determined.

See abstractor notes

Coding Manual: Hematopoietic Coding Manual (PDF)

Abstractor Notes

Hodgkin lymphoma, lymphocyte depletion includes diffuse fibrosis and reticular Hodgkin's disease from the Lukes and Butler classification. This neoplasm is now very rarely diagnosed, and it is recognized that many cases previously diagnosed as HD (lymphocyte-depletion) are in fact examples of non-Hodgkin's lymphoma, commonly of anaplastic large cell type Anaplastic Large Cell Lymphoma. The majority of cases of show morphological features of diffuse fibrosis characterized by a hypocellular background containing bizarre H-RS cells and associated with non-collagenous fibrosis.

This code should be used only for historic cases unless no other diagnosis is available.

Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.

Diagnostic Confirmation

This is a histology for which the Definitive Diagnostic Method does not include Genetics Data or Immunophenotyping, thus Diagnostic Confirmation should never be 3. If genetics and/or immunophenotyping are available, re-review to see if a more specific neoplasm can be coded.

Module Rule

None

Alternate Names

Classical Hodgkin lymphoma, lymphocyte depletion, reticular [OBS]

Definition

Hodgkin lymphoma, lymphocyte depletion, reticular is a subtype of Hodgkin lymphoma lymphocyte depletion, characterized by extremely large numbers of Hodgkin and Reed-Sternberg cells, some of which appear to be mummified. Diffuse effacement of normal lymph node structure; small lymphocytes, plasma cells, histiocytes, granulocytes are scanty. Foci of necrosis usually encountered.

Definitive Diagnostic Methods

Histologic confirmation

Genetics Data

None

Immunophenotyping

None

Treatments

Chemotherapy
Hormone therapy
Radiation therapy

Transformations to

None

Transformations from

Same Primaries

Corresponding ICD-10 Codes (Cause of Death codes only)

C81.3 Hodgkin lymphocytic depletion

Corresponding ICD-10-CM Codes (U.S. only)

C81.3 Lymphocyte depleted Hodgkin lymphoma (effective October 01, 2015)

Signs and Symptoms

Drenching night sweats
Fatigue
Fever
Pain the chest, abdomen, or bones (for no known reason)
Painless swelling in the lymph nodes in the neck, underarm, groin, or stomach
Peripheral lymphadenopathy
Skin rash or itchy skin
Weight loss (for no known reason)

Diagnostic Exams

Blood chemistry studies
Bone marrow aspiration and biopsy
CT (CAT) scan
Complete blood count
Erythrocyte sedimentation rate
Immunophenotyping
Lymph node biopsy
PET (positron emission tomography) scan

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

International Classification of Diseases for Oncology, 3rd edition (including revisions). Geneva: World Health Organization, 2001, 2011, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

PDQ® Adult Treatment Editorial Board. PDQ Hodgkin Lymphoma Treatment. Bethesda, MD: National Cancer Institute. Updated <01/13/2025>. Available at: https://www.cancer.gov/types/lymphoma/hp/adult-hodgkin-treatment-pdq. Accessed <02/05/2025>. [PMID: 26389473]
Section: Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version
Pages: https://www.cancer.gov/types/lymphoma/hp/adult-hodgkin-treatment-pdq#top
Glossary