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Appendix C brings together the site-specific instructions needed to abstract a case, facilitating efficiency and accuracy. The site-specific coding modules include SEER Coding Guidelines, Extent of Disease and Surgery of Primary Site codes1. Site-Specific Neoadjuvant Therapy Effect coding documents can now be found in SEER*RSA or the SSDI manual. General instructions in the main manual are applicable in the absence of site-specific instructions. All modules include the extent of disease and surgery codes and solid tumor coding rules. Some modules include site-specific coding guidelines. Additional site-specific coding instructions are found in SEER*RSA, the SSDI manual
, and the Grade manual.
Oral Cavity, Tonsil, Oropharynx
-
Coding Guidelines: Tongue (PDF, 347 KB)
Solid Tumor Rules: Head and Neck (PDF, 8.4 MB)
Surgery Codes
-
EOD Schemas
Parotid, Other and Unspecified Glands
-
Solid Tumor Rules: Head and Neck (PDF, 8.4 MB)
Surgery Codes
- Parotid and Other Unspecified Glands - (C079, C080-C089) (PDF, 142 KB)
EOD Schemas
Pharynx, Hypopharynx, Nasopharynx, Pyriform Sinus
-
Solid Tumor Rules: Head and Neck (PDF, 8.4 MB)
Surgery Codes
- Pharynx - (C090-C099, C100-C109, C110-C119, C129, C130-C139, C140) (PDF, 139 KB)
- All Other Sites - (C142-C148) (PDF, 157 KB)
-
EOD Schemas
Esophagus
-
Coding Guidelines: Esophagus (PDF, 142 KB)
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Esophagus - (C150-C159) (PDF, 138 KB)
-
EOD Schemas
Stomach
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Stomach - (C160-C169) (PDF, 144 KB)
-
EOD Schemas
Small Intestine
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C170-C179) (PDF, 157 KB)
-
EOD Schemas
Colon, Appendix, Rectosigmoid, Rectum
-
Coding Guidelines: Colon (PDF, 105 KB)
Coding Guidelines: Rectosigmoid, Rectum (PDF, 138 KB)
Solid Tumor Rules: Colon, Rectosigmoid, and Rectum (PDF, 8.4 MB)
Surgery Codes
- Colon - (C180-C189) (PDF, 197 KB)
- Rectosigmoid - (C199) (PDF, 168 KB)
- Rectum - (C209) (PDF, 166 KB)
-
EOD Schemas
Anus
-
Coding Guidelines: Anus (PDF, 233 KB)
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Anus - (C210-C218) (PDF, 140 KB)
EOD Schemas
Liver, Intrahepatic Bile Ducts
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Liver and Intrahepatic Bile Ducts - (C220-C221) (PDF, 158 KB)
-
EOD Schemas
Gallbladder, Extrahepatic Bile Ducts, Ampulla of Vater
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C239, C240-C249) (PDF, 157 KB)
-
EOD Schemas
Pancreas
-
Coding Guidelines: Pancreas (PDF, 161 KB)
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Pancreas - (C250-C259) (PDF, 135 KB)
-
EOD Schemas
Gastrointestinal Stromal Tumors
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C260-C269) (PDF, 157 KB)
EOD Schemas
Other Digestive
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C260-C269) (PDF, 157 KB)
EOD Schemas
Nasal Cavity, Middle Ear, Sinuses
-
Solid Tumor Rules: Head and Neck (PDF, 8.4 MB)
Surgery Codes
- All Other Sites - (C300-C301, C310-C319) (PDF, 157 KB)
-
EOD Schemas
Larynx
-
EOD Schemas
Trachea, Other Respiratory
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C339) (PDF, 157 KB)
-
EOD Schemas
Lung
-
Coding Guidelines: Lung (PDF, 108 KB)
Solid Tumor Rules: Lung (PDF, 8.4 MB)
Surgery Codes
- Lung - (C340-C349) (PDF, 172 KB)
-
EOD Schemas
Heart, Mediastinum, Pleura
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C380-C388, C390-C399) (PDF, 157 KB)
-
EOD Schemas
Bones, Joints, Cartilage
-
Coding Guidelines: Bones, Joints, Cartilage (PDF, 98 KB)
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
-
EOD Schemas
Skin
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Skin - (C440-C449) (PDF, 184 KB)
-
EOD Schemas
Melanoma
-
Coding Guidelines: Melanoma (PDF, 144 KB)
Solid Tumor Rules: Cutaneous Melanoma (PDF, 8.4 MB) - Use for cases diagnosed 2021 and later
Surgery Codes
- Skin - (C440-C449) (PDF, 184 KB)
- All Other Sites - (C510-C519, C600-C609, C632) (PDF, 157 KB)
-
EOD Schemas
Mycosis Fungoides, Sezary Disease
-
Hematopoietic and Lymphoid Neoplasm Coding Manual (PDF, 3.6 MB)
Surgery Codes
- Skin - (C440-C449) (PDF, 184 KB)
- Oral Cavity - (C000-C009, C019, C020-C029, C030-C039, C040-C049, C050-C059, C060-C069) (PDF, 140 KB)
- All Other Sites - (C510-C519, C600-C609, C632) (PDF, 157 KB)
EOD Schemas
Soft Tissues, Nerves, Nervous System
-
Coding Guidelines: Nerves, Nervous System, Soft Tissues (PDF, 98 KB)
Solid Tumor Rules: Malignant CNS and Peripheral Nerves (PDF, 8.4 MB)
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+Surgery Codes
-
EOD Schemas
Retroperitoneum, Peritoneum
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C480-C488) (PDF, 157 KB)
-
EOD Schemas
Breast
-
Coding Guidelines: Breast (PDF, 277 KB)
Solid Tumor Rules: Breast (PDF, 8.4 MB)
Surgery Codes
- Breast - (C500-C509) (PDF, 193 KB)
EOD Schemas
Vulva, Vagina
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C510-C519, C529) (PDF, 157 KB)
-
EOD Schemas
Cervix Uteri
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Cervix Uteri - (C530-C539) (PDF, 167 KB)
EOD Schemas
Corpus Uteri, Uterus, NOS
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Corpus Uteri - (C540-C559) (PDF, 169 KB)
-
EOD Schemas
- Adenosarcoma of the Corpus Uteri; Uterus, NOS
- Carcinoma and Carcinosarcoma of Corpus Uteri; Uterus, NOS (excluding Placenta and Adenosarcoma, Leiomyosarcoma, and Endometrial Stromal Sarcoma (ESS))
- Sarcoma (Leiomyosarcoma and Endometrial Stromal Sarcoma) of the Corpus Uteri; Uterus, NOS (excluding Placenta and Adenosarcoma, Carcinoma, and Carcinosaroma)
Ovary
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Ovary (C569) (PDF, 166 KB)
EOD Schemas
Fallopian Tube, Ligaments, Adnexa
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C570-C574) (PDF, 157 KB)
-
EOD Schemas
Other and Unspecified Female Genital Organs, Placenta
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C577-C579, C589) (PDF, 157 KB)
-
EOD Schemas
Penis
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C600-C609) (PDF, 157 KB)
EOD Schemas
Prostate
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Prostate - (C619) (PDF, 170 KB)
EOD Schemas
Testis
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Testis - (C620-C629) (PDF, 128 KB)
EOD Schemas
Other and Unspecified Male Genital Organs
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C630-C639) (PDF, 157 KB)
EOD Schemas
Kidney
-
Coding Guidelines: Kidney (PDF, 101 KB)
Solid Tumor Rules: Kidney (PDF, 8.4 MB)
Surgery Codes
- Kidney, Renal Pelvis, and Ureter - (C649, C659, C669) (PDF, 140 KB)
EOD Schemas
Renal Pelvis, Ureter
-
Coding Guidelines: Renal Pelvis and Ureter (PDF, 102 KB)
Solid Tumor Rules: Urinary (PDF, 8.4 MB)
Surgery Codes
- Kidney, Renal Pelvis, and Ureter - (C649, C659, C669) (PDF, 140 KB)
EOD Schemas
Bladder
-
Coding Guidelines: Bladder (PDF, 258 KB)
Solid Tumor Rules: Urinary (PDF, 8.4 MB)
Surgery Codes
- Bladder - (C670-C679) (PDF, 169 KB)
EOD Schemas
Urethra, Urinary Other
-
Coding Guidelines: Urethra (PDF, 103 KB)
Solid Tumor Rules: Urinary (PDF, 8.4 MB)
Surgery Codes
- All Other Sites - (C680-C689) (PDF, 157 KB)
-
EOD Schemas
Eye
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C690-C699) (PDF, 157 KB)
-
EOD Schemas
Brain, Central Nervous System, Malignant
-
Coding Guidelines: Brain, Central Nervous System, Malignant (PDF, 1.1 MB)
Solid Tumor Rules: Malignant CNS and Peripheral Nerves (PDF, 8.4 MB)
Surgery Codes
- Brain - (C700-C709, C710-C719, C720-C729) (PDF, 137 KB)
-
EOD Schemas
Brain, Central Nervous System, Benign and Borderline
-
Coding Guidelines: Brain, Central Nervous System, Benign and Borderline (PDF, 1.1 MB)
Solid Tumor Rules: Non-Malignant CNS (PDF, 8.4 MB)
Surgery Codes
- Brain - (C700-C709, C710-C719, C720-C729) (PDF, 137 KB)
-
EOD Schemas
Intracranial Glands
-
Coding Guidelines: Intracranial Glands (PDF, 295 KB)
Solid Tumor Rules: Non-Malignant CNS (PDF, 8.4 MB)
Solid Tumor Rules: Malignant CNS and Peripheral Nerves (PDF, 8.4 MB)
Surgery Codes
- All Other Sites – (C751, C752, C753) (PDF, 157 KB)
-
EOD Schemas
Thyroid
-
Coding Guidelines: Thyroid Gland (PDF, 167 KB)
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- Thyroid Gland - (C739) (PDF, 111 KB)
-
EOD Schemas
Thymus, Adrenal and Other Endocrine Glands
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- All Other Sites - (C379, C740-C749, C750, C754-C759) (PDF, 157 KB)
-
EOD Schemas
Kaposi Sarcoma
-
Coding Guidelines: Kaposi Sarcoma of All Sites (PDF, 127 KB)
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- See Site-specific Codes
EOD Schemas
Lymphoma
-
Coding Guidelines: Lymphoma (PDF, 192 KB)
Hematopoietic and Lymphoid Neoplasm Coding Manual (PDF, 3.6 MB)
Surgery Codes
- Lymph Nodes - (C770-C779) (PDF, 159 KB)
- See site-specific codes
-
EOD Schemas
Hematopoietic, Reticuloendothelial, Immunoproliferative and Myeloproliferative
-
Hematopoietic and Lymphoid Neoplasm Coding Manual (PDF, 3.6 MB)
Surgery Codes
-
EOD Schemas
Other and Unknown Sites
-
Solid Tumor Rules: Other Sites (PDF, 8.4 MB) - For cases diagnosed 1/1/2023+
Surgery Codes
- See Hematopoietic, Reticuloendothelial, Immunoproliferative, and Myeloproliferative Disease - (C420, C421, C423, C424) (PDF, 149 KB)
- Spleen - (C422) (PDF, 106 KB)
- Unknown and Ill-Defined Primary Sites - (C760-C768, C809) (PDF, 149 KB)
EOD Schemas
1The surgery codes are based on the American College of Surgeons Commission on Cancer's Standards for Oncology Registry Entry, American College of Surgeons, Chicago, IL, 60611-321 (STORE), Revised for 2026, Appendix B: Site-specific Surgery Codes. The surgery codes in this document are identical to the STORE manual; only formatting and annotations may vary. The SEER Notes that appear in the Surgery Code sections contain information or instructions not found in STORE or that are different from STORE.
