This is a document containing changes only. Do not use in place of the Solid Tumor Rules.

See the December 2022 Revisions
See the September 2021 Revisions
See the December 2020 Revisions
See the November 2020 Revisions
See the July 2019 Revisions
See the April 2019 Revisions
See the 2018 Revisions

Other Sites - May Update

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Terms and Definitions

  • All histology tables: Behavior codes were removed unless a histology only occurs with one behavior code
  • Table 2: Histology Combination Codes
    • 8340 row: Example deleted
  • Table 4: Testis Histologies
    • 9064 row: Histologies in the example corrected to 9084
  • Table 6: Stomach Histologies
    • 8144/2 and 8144/3 consolidated to one row
  • Table 7: Small Intestine and Ampulla of Vater Histologies
    • 8144/2 and 8144/3 consolidated to one row
  • Table 9: Liver and Intrahepatic Bile Duct Histologies
    • 8470/2 and 8470/3 consolidated to one row
  • Table 10: Gallbladder and Extrahepatic Bile Duct Histologies
    • 8503/2 and 8503/3 consolidated to one row
  • Table 11: Pancreas Histologies
    • 8453/2 and 8453/3 consolidated to one row
    • 8503/2 and 8503/3 consolidated to one row
    • 8470/2 and 8470/3 consolidated to one row
  • Table 12: Thyroid Histologies
    • 8260 row: Oncocytic variant of PTC code corrected to 8342
  • Table 21: C412-C414, C418, C419 added

Multiple Primary Rules

  • M Rule: Abstract multiple primaries when separate/non-contiguous tumors are anaplastic carcinoma and any other histologies in the thyroid.
    • Note added: “This rule does not apply to multiple tumors that are anaplastic carcinoma and undifferentiated carcinoma.”
  • M Rule: Tumors with ICD-O-3 topography codes that differ only at the fourth character…
    • Bullet deleted (no longer applies to 2023+ cases): Peripheral nerves and autonomic nervous system (C47_) (Cases diagnosed 1/1/2007 to 12/31/2017 ONLY)
  • The “different subtypes/variants” M rule now comes before the “same row” M rule to be consistent with all other Solid Tumor modules (the order was switched).
  • M Rule: Abstract multiple primaries when separate/non-contiguous tumors are two or more different subtypes/variants…
    • Histology codes in the bullets were corrected

Other Sites - March Update

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Terms and Definitions

  • Table 1: Paired Organs and Sites with Laterality
    • Row added: “C444 Skin of Scalp and Neck”
    • Rows C443 and C445: “If midline, assign code 5” (corrected from code 9)
  • Table 2: Histology Combination Codes
    • 8255 row, note added: “Code 8255 does not apply to GYN primaries. Continue through the table to determine correct mixed histology code for GYN neoplasms.”
    • 8340 row: Note and example added.
  • Table 3: Prostate Histologies
    • Acinar adenocarcinoma 8140 row
      • Subtype/variant deleted: "Adenocarcinoma with neuroendocrine differentiation 8574/3" (this histology erroneously appeared twice in the table)
  • Table 4: Testis Histologies
    • Germ cell tumor, NOS 9064/3:
      • Note added: “The following teratomas are not reportable:
        • Teratoma, prepubertal type 9064/0
        • Teratoma, mature, prepubertal type 9064/0”
    • Row added: “Seminoma, NOS 9061/3”
  • Table 12: Thyroid Histologies
    • Carcinoma, anaplastic 8021/3 row
      • “Carcinoma, Undifferentiated 8020/3” moved from synonyms to subtypes/variants
    • Papillary thyroid carcinoma, NOS 8260/3 row
      • “And papillary microcarcinoma” added to note and synonyms
      • Subtype/variant deleted: Non-invasive encapsulated follicular variant of papillary thyroid carcinoma 8343/2
  • Table 14: Peritoneum Histologies
    • Added “as noted in the 5th Ed WHO Female Genital Tumors only” to the intro
  • Table 15: Fallopian Tube Histologies
    • Serous carcinoma, NOS 8441/3 row
      • Subtype/variant added: “Low-grade serous carcinoma 8460/3”
  • Table 17: Uterine Cervix Histologies
    • Germ cell tumor NOS 9064/3 row
      • Subtypes/variants added:
        • “Choriocarcinoma NOS 9100/3”
        • “Endodermal sinus tumor/Yolk sac tumor 9071/3”
    • Mucoepidermoid carcinoma 8430/3 row
      • Subtypes/variants deleted:
        • “Choriocarcinoma NOS 9100/3”
        • “Endodermal sinus tumor/Yolk sac tumor 9071/3”
  • Table 19: Vulva Histologies
    • Neuroendocrine tumor, NOS 8240/3 row
      • Subtype/variant added: “Neuroendocrine tumor, grade 2 8249/3”
      • Synonym removed: “Neuroendocrine tumor, grade 2”
  • Table 20: Soft Tissue Histologies
    • Note added: “Table 20 lists sarcomas arising in the soft tissue sites listed below only. Soft tissue neoplasms can arise in other organs. See the site-specific Solid Tumor Modules.”
  • Table 21: Bone Histologies
    • Chordoma, NOS 9370/3 row
      • Subtype/variant added: “Chondroid chordoma 9371/3”
    • Row added: “Undifferentiated high grade pleomorphic sarcoma of bone 8830/3”

Multiple Primary Rules

  • New M Rule:
    • “Abstract multiple primaries when separate/non-contiguous tumors are two or more different subtypes/variants in Column 3, Table 3-21 in the Equivalent Terms and Definitions.”

Histology Coding Rules

  • “Coding Histology” section
    • Example added to Instruction #2: “Endometrioid carcinoma with squamous differentiation has an ICD-O code of 8570/3”
  • New H Rule: “Code 8077/2 (squamous intraepithelial neoplasia, high grade) for the following:…”
  • New H Rule: “Code 8148/2 (glandular intraepithelial neoplasia, grade III) for the following:…”
  • H Rule: Code the histology when only one histologic type is identified.
    • Note 2 and Example added (former Note 2 moved to Note 3)
  • H Rule: Code papillary carcinoma, follicular variant of thyroid (8340) when there are multiple papillary and follicular carcinoma subtypes/variants…
    • Note added
  • H Rule: Code 8077/2 (Squamous intraepithelial neoplasia, high grade) for the following:
    • Bullet removed: “biliary intraepithelial neoplasia, high grade”