Based on results from the February 2018 SEER submission of cases for 2016 rates and trends, the following figures and tables are presented. Caution is advised when interpreting this figure and these tables, as these are preliminary results and are subject to change for 2016 with the addition of data from more recent case submissions.

Preliminary 5-year Average Annual Percent Change (AAPC) Estimates
Based on Joinpoint Analyses 2000-2016 (with up to 3 joinpoints)

February 2018 SEER Submission, SEER 18 Registries

The graphs below present the Average Annual Percent Change (What is an AAPC?) for 2012-2016 based on the preliminary rates through 2016. The underlying rates in the analysis were adjusted for reporting delay in the registry.
An * next to the displayed value indicates that the AAPC is significantly different from zero (p<.05).

Preliminary 5-year AAPC Estimates
Male, All Races

Preliminary 5-year AAPC Estimates
Female, All Races

Preliminary 5-year AAPC Estimates
Male, White

Preliminary 5-year AAPC Estimates
Female, White

Preliminary 5-year AAPC Estimates
Male, Black

Preliminary 5-year AAPC Estimates
Female, Black

5-year Delay-Adjusted Ratesa

February 2018 SEER Submission (2000-2016), SEER 18 Registries

aRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

Cancer Site Sex Race Delay-adjusted ratesa 2012-2016
All SitesMaleAll Races487.8
White494.9
Black546.8
FemaleAll Races416.6
White431.8
Black411.2
All Sites (Ages 0-19)MaleAll Races18.9
White20.1
Black14.0
FemaleAll Races17.8
White18.9
Black13.8
Brain and Other Nervous SystemMaleAll Races7.7
White8.5
Black4.9
FemaleAll Races5.5
White6.1
Black3.5
BreastFemaleAll Races126.9
White129.6
Black129.3
CervixFemaleAll Races7.5
White7.5
Black8.5
Colon and RectumMaleAll Races45.5
White44.7
Black56.4
FemaleAll Races34.8
White34.3
Black42.7
Corpus and Uterus NOSFemaleAll Races26.1
White26.8
Black25.7
EsophagusMaleAll Races7.2
White7.8
Black6.5
FemaleAll Races1.7
White1.7
Black2.2
Hodgkin LymphomaMaleAll Races2.9
White3.0
Black3.2
FemaleAll Races2.2
White2.4
Black2.2
Kidney and Renal PelvisMaleAll Races22.0
White22.6
Black25.8
FemaleAll Races11.1
White11.5
Black13.1
LarynxMaleAll Races5.3
White5.3
Black8.3
FemaleAll Races1.1
White1.2
Black1.6
LeukemiaMaleAll Races19.2
White20.4
Black15.4
FemaleAll Races11.7
White12.5
Black9.8
Liver and Intrahepatic Bile DuctMaleAll Races13.9
White12.4
Black17.6
FemaleAll Races4.8
White4.4
Black5.1
Lung and BronchusMaleAll Races64.4
White64.6
Black82.0
FemaleAll Races48.3
White50.9
Black48.8
Melanoma of the SkinMaleAll Races29.8
White35.7
Black1.2
FemaleAll Races17.7
White21.8
Black1.1
MyelomaMaleAll Races8.9
White8.4
Black17.1
FemaleAll Races5.7
White5.0
Black12.7
Non-Hodgkin LymphomaMaleAll Races24.1
White25.3
Black17.9
FemaleAll Races16.3
White17.2
Black12.5
Oral Cavity and PharynxMaleAll Races17.3
White18.3
Black14.2
FemaleAll Races6.4
White6.6
Black5.3
OvaryFemaleAll Races11.8
White12.3
Black9.5
PancreasMaleAll Races14.6
White14.7
Black17.2
FemaleAll Races11.4
White11.2
Black14.6
ProstateMaleAll Races114.1
White108.2
Black185.9
StomachMaleAll Races9.9
White9.0
Black13.7
FemaleAll Races5.2
White4.5
Black7.7
TestisMaleAll Races5.8
White6.9
Black1.5
ThyroidMaleAll Races7.4
White7.9
Black3.9
FemaleAll Races21.6
White23.0
Black13.6
Urinary BladderMaleAll Races34.7
White38.2
Black21.1
FemaleAll Races8.4
White9.1
Black6.9

aRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

Joinpoint Trend Analyses

November 2017 SEER Submission (2000-2015, with up to 2 Joinpoints) and
February 2018 SEER Submission (2000-2016, with up to 3 Joinpoints)
SEER 18 Registries

The numbers presented in the table below represent the Annual Percent Change (APC) in incidence rates. An APC is estimated based on a model that fits a linear trend to the log of the annual incidence rate. This model also estimates whether a trend changes significantly in direction or magnitude and, if it does, determines when the change(s) occurs. If a trend does not change over time, then there is only one estimate provided for the entire time period. If there is one or more points where a trend changes, the table shows each APC estimate and the years for which each estimate applies. For more information about the model used to estimate these trends, visit Joinpoint Trend Analysis Software.

* The APC is significantly different from zero (p<.05).

Cancer Site Sex Race Joinpoint Trends 2000-2015
APC (Year Range)
Preliminary Joinpoint Trends 2000-2016
APC (Year Range)
All SitesMaleAll Races-0.7* (2000-08)
-2.1* (2008-15)
-0.7* (2000-08)
-2.1* (2008-16)
White-0.6* (2000-08)
-2.1* (2008-15)
-0.6* (2000-08)
-2.0* (2008-16)
Black-1.3* (2000-09)
-3.1* (2009-15)
-1.3* (2000-09)
-3.0* (2009-16)
FemaleAll Races-0.0 (2000-15)-0.0 (2000-16)
White0.0 (2000-15)0.0 (2000-16)
Black0.2* (2000-15)0.1* (2000-16)
All Sites (Ages 0-19)MaleAll Races0.7* (2000-15)0.7* (2000-16)
White0.6* (2000-15)0.6* (2000-16)
Black1.3* (2000-15)1.2* (2000-16)
FemaleAll Races1.2* (2000-15)1.2* (2000-16)
White1.1* (2000-15)1.1* (2000-16)
Black1.6* (2000-15)1.5* (2000-16)
Brain and Other Nervous SystemMaleAll Races-0.2 (2000-15)-0.2* (2000-16)
White-0.1 (2000-15)-0.1 (2000-16)
Black0.0 (2000-15)-0.1 (2000-16)
FemaleAll Races-0.1 (2000-15)-0.2 (2000-16)
White-0.0 (2000-15)-0.1 (2000-16)
Black-0.3 (2000-15)-0.6 (2000-16)
BreastFemaleAll Races-2.3* (2000-04)
0.3* (2004-15)
-2.3* (2000-04)
0.3* (2004-16)
White-2.5* (2000-04)
0.2 (2004-15)
-2.4* (2000-04)
0.2 (2004-16)
Black0.7* (2000-15)0.6* (2000-16)
CervixFemaleAll Races-3.7* (2000-03)
-1.5* (2003-13)
2.0 (2013-15)
-3.8* (2000-03)
-1.4* (2003-13)
1.1 (2013-16)
White-4.3 (2000-03)
-0.8* (2003-15)
-4.8* (2000-03)
-0.0 (2003-08)
-2.2* (2008-13)
2.9* (2013-16)
Black-2.8* (2000-15)-2.8* (2000-16)
Colon and RectumMaleAll Races-2.5* (2000-08)
-3.7* (2008-12)
-0.6 (2012-15)
-2.7* (2000-16)
White-2.7* (2000-08)
-3.9* (2008-12)
-0.2 (2012-15)
-3.0* (2000-12)
-1.6 (2012-16)
Black-2.4* (2000-15)-2.5* (2000-16)
FemaleAll Races-2.0* (2000-08)
-3.6* (2008-11)
-1.3* (2011-15)
-2.0* (2000-08)
-3.5* (2008-11)
-1.3* (2011-16)
White-2.2* (2000-08)
-3.5* (2008-11)
-0.9 (2011-15)
-2.4* (2000-13)
-0.4 (2013-16)
Black-1.4* (2000-07)
-3.1* (2007-15)
-1.3* (2000-06)
-2.9* (2006-16)
Corpus and Uterus NOSFemaleAll Races-1.5 (2000-03)
1.5* (2003-15)
-1.5 (2000-03)
1.4* (2003-16)
White-1.9 (2000-03)
1.3* (2003-15)
-1.9 (2000-03)
1.3* (2003-16)
Black2.3* (2000-15)2.3* (2000-16)
EsophagusMaleAll Races-0.9* (2000-15)-1.0* (2000-16)
White-0.3 (2000-15)-0.4* (2000-16)
Black-4.8* (2000-15)-4.8* (2000-16)
FemaleAll Races-1.6* (2000-15)-1.5* (2000-16)
White-1.0* (2000-15)-1.0* (2000-16)
Black-3.9* (2000-15)-3.9* (2000-16)
Hodgkin LymphomaMaleAll Races1.1 (2000-07)
-1.6* (2007-15)
1.1 (2000-07)
-1.6* (2007-16)
White1.2 (2000-07)
-2.0* (2007-15)
1.1 (2000-07)
-1.8* (2007-16)
Black0.6 (2000-15)0.3 (2000-16)
FemaleAll Races1.0 (2000-08)
-2.6* (2008-15)
2.3 (2000-05)
-1.6* (2005-16)
White1.2 (2000-07)
-2.4* (2007-15)
1.1 (2000-07)
-2.1* (2007-16)
Black0.3 (2000-15)0.4 (2000-16)
Kidney and Renal PelvisMaleAll Races3.2* (2000-08)
-0.6 (2008-11)
1.4* (2011-15)
3.0* (2000-08)
0.5 (2008-16)
White3.0* (2000-08)
0.5 (2008-15)
3.0* (2000-08)
0.5* (2008-16)
Black3.4* (2000-08)
0.6 (2008-15)
3.2* (2000-09)
-0.1 (2009-16)
FemaleAll Races3.6* (2000-07)
0.5 (2007-15)
3.6* (2000-07)
0.5 (2007-16)
White4.1* (2000-06)
0.7* (2006-15)
3.7* (2000-07)
0.5 (2007-16)
Black2.0 (2000-05)
7.1 (2005-08)
0.0 (2008-15)
3.8* (2000-09)
0.3 (2009-16)
LarynxMaleAll Races-4.4* (2000-03)
-1.8* (2003-11)
-4.0* (2011-15)
-4.3* (2000-03)
-1.8* (2003-11)
-3.6* (2011-16)
White-4.1* (2000-03)
-1.4* (2003-11)
-4.2* (2011-15)
-2.3* (2000-16)
Black-3.3* (2000-15)-3.3* (2000-16)
FemaleAll Races-2.1* (2000-15)-2.1* (2000-16)
White-2.0* (2000-15)-2.0* (2000-16)
Black-1.7* (2000-15)-1.9* (2000-16)
LeukemiaMaleAll Races-0.4 (2000-06)
1.5* (2006-15)
-0.4 (2000-07)
3.1 (2007-10)
0.6 (2010-16)
White-0.2 (2000-06)
1.6* (2006-15)
-0.1 (2000-06)
1.5* (2006-16)
Black0.5 (2000-15)0.5 (2000-16)
FemaleAll Races-0.2 (2000-05)
1.4* (2005-15)
-0.1 (2000-05)
1.3* (2005-16)
White1.2* (2000-15)1.1* (2000-16)
Black-1.2 (2000-07)
2.4* (2007-15)
-1.2 (2000-07)
2.2* (2007-16)
Liver and Intrahepatic Bile DuctMaleAll Races4.2* (2000-09)
2.1* (2009-15)
4.3* (2000-09)
1.8* (2009-16)
White0.7 (2000-02)
5.3* (2002-09)
2.4* (2009-15)
0.4 (2000-02)
5.6* (2002-08)
3.0* (2008-14)
-0.6 (2014-16)
Black3.6* (2000-15)3.2* (2000-16)
FemaleAll Races3.1* (2000-15)3.1* (2000-16)
White-0.2 (2000-03)
4.2* (2003-15)
0.3 (2000-03)
4.0* (2003-16)
Black3.2* (2000-15)3.3* (2000-16)
Lung and BronchusMaleAll Races-1.9* (2000-08)
-3.0* (2008-15)
-2.0* (2000-09)
-3.2* (2009-16)
White-1.8* (2000-08)
-3.0* (2008-15)
-1.8* (2000-08)
-3.1* (2008-16)
Black-2.8* (2000-15)-2.9* (2000-16)
FemaleAll Races0.1 (2000-07)
-1.7* (2007-15)
0.1 (2000-07)
-1.7* (2007-16)
White0.1 (2000-07)
-1.6* (2007-15)
0.1 (2000-07)
-1.6* (2007-16)
Black1.6* (2000-05)
-1.5* (2005-15)
1.2 (2000-06)
-1.8* (2006-16)
Melanoma of the SkinMaleAll Races2.0* (2000-15)1.7* (2000-16)
White2.2* (2000-15)2.0* (2000-16)
Black-0.3 (2000-15)-0.8 (2000-16)
FemaleAll Races1.5* (2000-15)1.4* (2000-16)
White1.8* (2000-15)1.7* (2000-16)
Black0.9 (2000-15)0.4 (2000-16)
MyelomaMaleAll Races1.7* (2000-15)1.7* (2000-16)
White1.7* (2000-15)1.7* (2000-16)
Black1.6* (2000-15)1.6* (2000-16)
FemaleAll Races1.4* (2000-15)-0.0 (2000-06)
2.2* (2006-16)
White1.3* (2000-15)-0.3 (2000-06)
2.2* (2006-16)
Black1.9* (2000-15)2.0* (2000-16)
Non-Hodgkin LymphomaMaleAll Races1.1* (2000-05)
-0.1 (2005-15)
0.7* (2000-08)
-0.5 (2008-16)
White0.9* (2000-07)
-0.2 (2007-15)
1.0* (2000-07)
-0.4 (2007-16)
Black0.1 (2000-15)0.1 (2000-16)
FemaleAll Races1.0 (2000-04)
-0.3* (2004-15)
1.1 (2000-04)
-0.4* (2004-16)
White0.6 (2000-06)
-0.4* (2006-15)
0.6 (2000-06)
-0.5* (2006-16)
Black0.4 (2000-15)0.4* (2000-16)
Oral Cavity and PharynxMaleAll Races-0.5 (2000-05)
1.1* (2005-15)
-0.5 (2000-05)
1.0* (2005-16)
White0.0 (2000-05)
1.5* (2005-15)
0.1 (2000-05)
1.4* (2005-16)
Black-2.2* (2000-15)-4.3* (2000-05)
-1.4* (2005-16)
FemaleAll Races0.1 (2000-15)0.1 (2000-16)
White0.4* (2000-15)0.4* (2000-16)
Black-0.8 (2000-15)-0.9* (2000-16)
OvaryFemaleAll Races-1.4* (2000-15)-1.5* (2000-16)
White-1.5* (2000-15)-1.6* (2000-16)
Black-0.8* (2000-15)-0.8* (2000-16)
PancreasMaleAll Races0.9* (2000-15)0.9* (2000-16)
White1.0* (2000-15)1.0* (2000-16)
Black0.3 (2000-15)0.2 (2000-16)
FemaleAll Races0.9* (2000-15)0.9* (2000-16)
White1.1* (2000-15)1.1* (2000-16)
Black0.2 (2000-15)0.1 (2000-16)
ProstateMaleAll Races-1.6* (2000-09)
-6.8* (2009-15)
-1.8* (2000-10)
-9.0* (2010-14)
3.0 (2014-16)
White-1.7* (2000-09)
-7.2* (2009-15)
-1.5 (2000-08)
-5.8* (2008-16)
Black-1.9* (2000-10)
-6.8* (2010-15)
-2.0* (2000-11)
-9.6* (2011-14)
3.1 (2014-16)
StomachMaleAll Races-1.3* (2000-15)-1.4* (2000-16)
White-1.0* (2000-15)-1.1* (2000-16)
Black-0.8 (2000-08)
-7.7 (2008-11)
1.0 (2011-15)
-0.7 (2000-08)
-8.1 (2008-11)
2.6 (2011-14)
-6.7 (2014-16)
FemaleAll Races-0.6* (2000-15)-0.6* (2000-16)
White-0.4* (2000-15)-0.3 (2000-16)
Black-1.6* (2000-15)-1.7* (2000-16)
TestisMaleAll Races0.8* (2000-15)0.8* (2000-16)
White0.8* (2000-15)0.8* (2000-16)
Black1.0 (2000-15)1.0 (2000-16)
ThyroidMaleAll Races6.2* (2000-09)
2.7* (2009-15)
5.7* (2000-11)
0.9 (2011-16)
White6.3* (2000-09)
2.5* (2009-15)
6.5* (2000-09)
2.0* (2009-16)
Black4.1* (2000-15)3.6* (2000-16)
FemaleAll Races7.0* (2000-09)
2.1* (2009-15)
6.9* (2000-09)
2.4* (2009-14)
-1.9 (2014-16)
White7.1* (2000-09)
2.0* (2009-15)
7.1* (2000-09)
2.3* (2009-14)
-1.5 (2014-16)
Black5.4* (2000-15)5.7* (2000-14)
-4.4 (2014-16)
Urinary BladderMaleAll Races0.1 (2000-06)
-1.3* (2006-15)
0.1 (2000-07)
-1.6* (2007-16)
White0.2 (2000-06)
-1.2* (2006-15)
-0.3 (2000-10)
-1.9* (2010-16)
Black0.0 (2000-15)0.4 (2000-13)
-4.6 (2013-16)
FemaleAll Races-1.0* (2000-15)-1.0* (2000-16)
White-0.9* (2000-15)-1.0* (2000-16)
Black-0.8* (2000-15)-0.7* (2000-16)
* The APC is significantly different from zero (p<.05).