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Oncotype DX

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Access the Database

To request access this specialized database, you must already have access to the latest SEER Reasearch Plus Data.

  • If you do not have access to SEER Research Plus Data, first request Access to the SEER data.
  • If you already have access, use the request options below.

Required Information:

  • Contact Information
  • SEER*Stat Username
  • Purpose and Analysis Plan

Submit a Request

This database includes Oncotype DX® related variables for invasive breast cancer (IBC) cases diagnosed between 2004 and 2015. These variables are obtained through linkage of all IBC diagnosed in SEER registries (excluding Alaska Native Tumor Registry) to Oncotype DX test orders and results provided by Genomic Health Clinical Laboratory. The Oncotype DX variables are appended to the SEER Research Data file which contains all IBC cases diagnosed between 2004 and 2015 and thus, includes cases for which Oncotype DX was not clinically indicated.

The database is available in the rate, frequency, survival, left-truncated survival, and case listing sessions in SEER*Stat for the November 2018 data submission.

Variables Included in this Database

The Breast with Oncotype DX databases includes the following variables:

  • Variables included in the standard SEER Incidence Data (PDF).
  • Additional treatment fields, which require a data use agreement for access to these fields regardless of whether you intend to use them. See radiation/chemotherapy for more information.
  • Oncotype DX® related variables.

All Oncotype DX® variables are linked variables provided by Genomic Health except 'Oncotype DX months since diagnosis', which is a calculated variable.

Variable Name in SEER*Stat Values Definition
Oncotype DX Breast Recurrence Score 0 to 100 Recurrence Score provided by Genomic Health
Oncotype DX RS group (RS < 18, RS 18-30, RS > 30)
  1. low
  2. intermediate
  3. high
 Based on the Recurrence Score categorized in 3 risk groups: low-RS<18; intermediate- RS 18-30; high - RS>30
Oncotype DX reason no score linked
  1. Cancelled Test - Cancelled by physician or patients before result was returned;
  2. Failed Test - Inadequate tissue sample;
  3. Outside Analysis Criteria; 
  4. Non-Unique - Patient had multiple tumors;

Mutually exclusive with 'Oncotype DX Breast Recurrence Score' and 'Oncotype DX RS group (RS < 18, RS 18-30, RS > 30)' and created to capture test orders for which result was not provided through linkage.

  1. Test was ordered, but was canceled by patient or provider prior to releasing the test results
  2. Test failed due to insufficient tissue and no further specimen was submitted for this case
  3. HR- and/or HER2+ by RT-PCR This refers to cases in which testing of estrogen receptor and progesterone receptor was negative and/or HER2 was positive by Genomic Health RT-PCR
  4. The case was associated with multiple tests on the same tumor or different tumors.
Oncotype DX year of test report 2004+ The year in which the test was reported
Oncotype DX month of test report January-December The month in which the test was reported
Oncotype DX months since diagnosis 1+ Calculated variable based on the difference between report month/year and diagnosis month/year