Search Database ICD-O-3 Code Lists

Name

Acute myeloid leukemia without maturation

ICD-O-3 Morphology

9873/3: Acute myeloid leukemia without maturation
Effective 2001 and later

Reportable

for cases diagnosed 2001 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Coding Manual: Hematopoietic Coding Manual (PDF)

Abstractor Notes

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10

Diagnostic Confirmation

This histology can be determined by positive histology (including peripheral blood) with or without genetics and/or immunophenotyping. Review the Definitive Diagnostic Methods, Immunophenotyping and Genetics Data sections below, and the instructions in the Hematopoietic Manual for further guidance on assigning Diagnostic confirmation.

Grade

Not Applicable

Module Rule

See abstractor notes

Alternate Names

Acute myeloblastic leukemia without maturation
Acute myeloid leukemia, M1
AML without maturation
FAB M1

Definition

Acute myeloid leukemia (AML) without maturation is characterized by a high percentage of bone marrow blasts without significant evidence of maturation to more mature neutrophils, maturing cells of the granulocytic lineage constitute < 10% of the nucleated bone marrow cells.

Definitive Diagnostic Methods

Bone marrow biopsy
Immunophenotyping

Genetics Data

None

Immunophenotyping

CD3- (no expression/negative)
CD7+ (expression/positive)
CD11b+ (expression/positive)
CD13+ (expression/positive)
CD22- (no expression/negative)
CD33+ (expression/positive)
CD34+ (expression/positive)
CD79a- (no expression/negative)
KIT (CD117)+ (expression/positive)
HLA-DR+ (expression/positive)
MPO+ (expression/positive)

Treatments

Chemotherapy

Transformations to

None

Transformations from

Same Primaries

Corresponding ICD-9 Codes

205.0 Acute myeloid leukemia

Corresponding ICD-10 Codes

C92.0 Acute myeloid leukemia

Corresponding ICD-10-CM Codes (U.S. only)

C92.0 Acute myeloblastic leukemia (effective October 01, 2015)

Signs and Symptoms

Anemia
Bone marrow failure
Easy bruising or bleeding
Fatigue
Fever
Leukocytosis
Neutropenia
Petechiae
Shortness of breath
Thrombocytopenia
Weakness
Weight loss or loss of appetite

Diagnostic Exams

Bone marrow aspiration and biopsy
CT (CAT) scan
Cytogenetic analysis
Immunophenotyping
Lumbar puncture
Peripheral blood smear

Progression and Transformation

None

Epidemiology and Mortality

Age: 46 years median age
Incidence: 5-10% of all AML cases

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 157-158

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

National Cancer Institute
Section: General Information About Acute Myeloid Leukemia
Pages: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq
Glossary