Search Database ICD-O-3 Code Lists

Name

Acute myelomonocytic leukemia, NOS (AMML)

ICD-O-3 Morphology

9867/3: Acute myelomonocytic leukemia
Effective 2001 and later

Reportable

for cases diagnosed 1978 and later

Primary Site(s)

C421

Coding Manual: Hematopoietic Coding Manual (PDF)

Abstractor Notes

Acute myelomonocytic leukemia, NOS (AMML) is part of the Acute myeloid leukemia (AML) lineage table in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B6)

This leukemia predominantly involves the peripheral blood and bone marrow.

If this leukemia and myeloid sarcoma (9930/3) occur during the same clinical workup, this is one primary, the leukemia.

If the myeloid sarcoma occurs after the diagnosis of the leukemia, that is a manifestation of the leukemia and is the same primary.

See Multiple Primary Rule M3

Diagnostic Confirmation

This histology can be determined by positive histology (including peripheral blood) with or without genetics and/or immunophenotyping. Review the Definitive Diagnostic Methods, Immunophenotyping and Genetics Data sections below, and the instructions in the Hematopoietic Manual for further guidance on assigning Diagnostic confirmation.

Module Rule

See abstractor notes

Alternate Names

Acute myeloid leukemia, M4 (FAB M4)

Definition

Acute myelomonocytic leukemia is an acute myeloid leukemia (AML) with evidence of granulocytic and monocytic maturation that lacks defining genetic abnormalities. (WHO 5th edition)

Definitive Diagnostic Methods

Histologic confirmation
Immunohistochemistry
Immunophenotyping

Genetics Data

None

Immunophenotyping

CD4 monocytic differentiation
CD7+ (expression/positive)
CD11b monocytic differentiation
CD11c monocytic differentiation
CD13+ (expression/positive)
CD14 monocytic differentiation
CD15+ (expression/positive)
CD33+ (expression/positive)
CD36 monocytic differentiation
CD56+ (expression/positive)
CD64 monocytic differentiation
CD65+ (expression/positive)
CD163 monocytic differentiation
KIT (CD117)+ (expression/positive)

Treatments

Chemotherapy
Hematologic Transplant and/or Endocrine Procedures

Transformations to

None

Transformations from

Same Primaries

Corresponding ICD-10 Codes (Cause of Death codes only)

C92.5 Acute myelomonocytic leukemia

Corresponding ICD-10-CM Codes (U.S. only)

C92.5 Acute myelomonocytic leukemia (effective October 01, 2015 - September 30, 2024)
C92.50 Acute myelomonocytic leukemia not having achieved remission (effective October 01, 2024)
C92.51 Acute myelomonocytic leukemia, in remission (effective October 01, 2024)
C92.52 Acute myelomonocytic leukemia, in relapse (effective October 01, 2024)

Signs and Symptoms

Anemia
Easy bruising or bleeding
Fatigue
Fever
High white blood cell count with numerous blasts and promonocytes
Petechiae
Thrombocytopenia
Shortness of breath
Weakness
Weight loss or loss of appetite

Diagnostic Exams

Bone marrow aspiration and biopsy
CT (CAT) scan
Cytogenetic analysis
Flow cytometry
Immunophenotyping
Lumbar puncture
Molecular analysis
Peripheral blood smear
Physical exam and history

Progression and Transformation

None

Epidemiology and Mortality

Age: 50 years median age
Incidence: 5-10% of all AML cases
Sex: female predominance

Sources

WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). https://publications.iarc.who.int/637.
Section: Acute myeloid leukemia
Pages: Part A: 155-156

International Classification of Diseases for Oncology, 3rd edition (including revisions). Geneva: World Health Organization, 2001, 2011, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

PDQ® Adult Treatment Editorial Board. PDQ Acute Myeloid Leukemia Treatment. Bethesda, MD: National Cancer Institute. Updated <03/06/2024>. Available at: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq. Accessed <02/06/2025>. [PMID: 26389432]
Section: Acute Myeloid Leukemia Treatment (PDQ®)–Health Professional Version
Pages: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq
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