Statistics at a Glance

At a Glance

Based on estimates of new cancer cases in 2022, 4.5% of all new cases will occur among ages 15 to 39. 85.5% of AYAs diagnosed with cancer will survive their cancer for 5 years after diagnosis.


4.5%

Cancers diagnosed among AYAs, ages 15–39, 4.5%.

5-Year
Relative Survival

85.5% SEER 17, 2012–2018

New Cancer Cases, 2022

Estimated New Cancers Among AYAs in the U.S. in 2022 87,050

% of All New Cancer Cases at Any Age 4.5%

Common Types of New Cancers Among AYAs

Thyroid Cancer 11.879334697 (16%)
Breast Cancer 11.412105923 (15%)
Melanoma of the Skin 5.863655182 (8%)
Testicular Cancer 5.828600562 (8%)
Other 41.201956244 (54%)

Distribution based on age-adjusted rates of new cases.
SEER 22, 2015–2019.


Cancer Deaths, 2022

Estimated Cancer Deaths Among AYAs the U.S. in 2022 9,180

% of All Cancer Deaths at Any Age 1.5%

Common Cancer Types Causing Death Among AYAs

Breast Cancer 1.124399279 (13%)
Brain and Other Nervous System (ONS) Cancer 0.96608688 (11%)
Leukemia 0.887328853 (10%)
Colorectal Cancer 0.877781757 (10%)
Other 4.96436122 (56%)

Distribution based on age-adjusted death rates.
U.S. Mortality, 2015–2019.

In 2022, it is estimated that there will be 87,050 new cases of cancer among AYAs and 9,180 deaths due to cancer among AYAs.

Trends in Age-adjusted Incidence and Mortality Rates
Year Rate of New Cases — SEER 8 Rate of New Cases — SEER 12 Death Rate — U.S. 5-Year Relative Survival — SEER 8
Observed Modeled Trend Observed Modeled Trend Observed Modeled Trend Observed Modeled Trend
1975 58.15 58.37 - - 16.45 16.08 70.35% 71.27%
1976 57.76 58.49 - - 16.12 15.90 72.47% 71.71%
1977 59.75 58.61 - - 15.88 15.72 72.89% 72.14%
1978 58.84 58.73 - - 15.25 15.55 72.21% 72.57%
1979 58.96 58.85 - - 15.08 15.37 72.14% 72.99%
1980 58.74 58.97 - - 15.33 15.20 73.93% 73.41%
1981 59.47 60.38 - - 14.68 15.03 74.09% 73.82%
1982 61.47 61.82 - - 14.85 14.86 74.03% 73.15%
1983 62.60 63.29 - - 14.49 14.70 72.71% 72.46%
1984 65.24 64.80 - - 14.64 14.53 70.24% 71.77%
1985 66.96 66.35 - - 14.52 14.37 70.42% 71.06%
1986 68.70 67.93 - - 14.42 14.21 70.85% 70.33%
1987 70.75 69.55 - - 13.91 14.05 69.18% 69.59%
1988 71.20 71.21 - - 13.73 13.89 67.77% 68.84%
1989 72.91 72.91 - - 13.55 13.74 68.13% 68.07%
1990 73.80 74.65 - - 13.59 13.58 67.71% 67.29%
1991 72.24 73.41 - - 13.52 13.43 68.44% 66.49%
1992 73.48 72.19 71.40 70.08 13.38 13.28 68.94% 68.77%
1993 69.44 70.99 66.76 68.85 12.81 13.00 71.03% 70.92%
1994 69.86 69.81 67.48 67.64 12.76 12.72 72.04% 72.96%
1995 69.88 68.65 67.74 66.45 12.53 12.44 73.48% 74.88%
1996 67.52 67.51 65.34 65.28 12.29 12.18 77.63% 76.68%
1997 66.28 66.39 63.10 64.13 12.03 11.92 79.59% 78.38%
1998 64.95 65.29 62.38 63.00 11.80 11.66 80.42% 79.97%
1999 65.91 66.25 63.34 63.66 11.30 11.41 81.23% 81.45%
2000 67.75 67.23 64.12 64.33 11.06 11.17 81.01% 81.98%
2001 68.02 68.22 65.01 65.01 11.11 10.93 81.80% 82.49%
2002 69.27 69.23 65.57 65.70 10.79 10.69 82.90% 82.99%
2003 71.08 70.25 66.18 66.39 10.46 10.46 83.75% 83.47%
2004 71.61 71.28 67.60 67.10 10.06 10.24 84.43% 83.95%
2005 72.23 72.34 68.84 67.81 9.90 10.02 85.25% 84.41%
2006 70.94 73.40 67.91 68.52 9.88 9.80 84.78% 84.86%
2007 74.42 74.48 69.89 69.25 9.49 9.59 85.47% 85.30%
2008 76.99 75.58 73.08 69.98 9.49 9.51 86.75% 85.72%
2009 76.36 75.82 71.90 70.72 9.66 9.43 86.11% 86.14%
2010 74.55 76.06 70.41 71.46 9.33 9.35 86.58% 86.54%
2011 75.65 76.30 71.20 72.22 9.23 9.27 86.74% 86.93%
2012 76.59 76.54 73.19 72.98 9.09 9.19 87.23% 87.31%
2013 75.38 76.78 72.05 73.75 9.02 9.11 87.45% 87.69%
2014 78.47 77.02 74.59 74.53 9.05 9.03 87.34% 88.05%
2015 78.97 77.26 75.56 75.32 8.91 8.96 - 88.40%
2016 80.38 77.50 76.27 76.12 9.04 8.88 - 88.74%
2017 77.53 77.75 74.37 75.09 8.77 8.81 - 89.07%
2018 75.75 77.99 73.39 74.08 8.80 8.73 - 89.40%
2019 77.48 78.24 73.78 73.09 8.60 8.66 - 89.71%

Modeled trend lines were calculated from the underlying rates using the Joinpoint Trend Analysis Software.

Using statistical models for analysis, rates of new cancer cases of any site among AYAs have been rising on average 0.3% each year over 2010–2019, the last 10 years of available data. Death rates have been falling on average 0.9% each year over 2010–2019.

Survival Statistics

How Many AYAs Survive 5 Years Or More after Being Diagnosed with Cancer?

Relative survival is an estimate of the percentage of patients who would be expected to survive the effects of their cancer. It excludes the risk of dying from other causes. Because survival statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. No two patients are entirely alike, and treatment and responses to treatment can vary greatly.

85.5%

5-Year
Relative Survival

85.5%

Based on data from SEER 17 2012–2018. Gray figures represent AYAs who have died from cancer within 5 years of diagnosis. Green figures represent those who have survived 5 years or more.

5-year Relative Survival by Sex and Race

5-Year Relative Survival

Total 85.5
Males 82.3
Females 87.5
NH White 88.7
NH Black 75.4
NH Asian or Pacific Islander 83.8
NH American Indian/Alaska Native 82.3
Hispanic 81.7

SEER 17 2012–2018, Ages 15–39
a Non-Hispanic, b Asian/Pacific Islander, c American Indian / Alaska Native

How Does Cancer Survival Among AYAs Compare to Cancer Survival at Other Ages?

5-Year Relative Survival

`
0–1485.148166823
15–39 85.467278042
40–64 73.628653419
65+ 60.676753763

SEER 17 2012–2018

New Cases and Deaths

New Cancers Among AYAs

The most common cancer type among AYAs is female breast cancer, with an age-adjusted rate of 22.9 new cases per 100,000 female AYAs, followed by thyroid cancer (11.9 per 100,000 AYAs) and testicular cancer (11.5 per 100,000 male AYAs). The 10 most common cancers among AYAs represent about 75% of new cancers among AYAs.

Rates of New Cases by Cancer Type and Sex
Male
Thyroid Cancer 4.471823791
Breast Cancer 0.072798879
Melanoma of the Skin 4.165147496
Testicular Cancer 11.492164383
Colorectal Cancer 4.983147228
Non-Hodgkin Lymphoma 4.646588618
Leukemia 4.154425012
Hodgkin Lymphoma 3.502713598
Cervical Cancer 0
Brain and Other Nervous System (ONS) Cancer 3.200917082
Female
Thyroid Cancer 19.462106958
Breast Cancer 22.889246015
Melanoma of the Skin 7.602117791
Testicular Cancer 0
Colorectal Cancer 5.08358642
Non-Hodgkin Lymphoma 3.354131665
Leukemia 2.9691037
Hodgkin Lymphoma 3.384211932
Cervical Cancer 6.528802254
Brain and Other Nervous System (ONS) Cancer 2.492208907

Age-adjusted rates of new cases per 100,000. SEER 22, 2015–2019.

Cancer Deaths Among AYAs

Female breast cancer is the deadliest cancer among AYAs with an age-adjusted death rate of 2.2 per 100,000 female AYAs, followed by brain and other nervous system (ONS) cancer (1.0 per 100,000 AYAs) and cervical cancer (0.9 per 100,000 female AYAs). The 10 deadliest cancers among AYAs represent about 70% of cancer deaths among AYAs.

Death Rates by Cancer Type and Sex
Male
Breast Cancer 0.008561851
Brain and Other Nervous System (ONS) Cancer 1.155437885
Leukemia 1.05162555
Colorectal Cancer 0.972650309
Cervical Cancer 0
Soft Tissue Cancer 0.485287774
Lung and Bronchus Cancer 0.40266118
Non-Hodgkin Lymphoma 0.466036454
Bone and Joint Cancer 0.39676875
Stomach Cancer 0.327203118
Female
Breast Cancer 2.248810639
Brain and Other Nervous System (ONS) Cancer 0.77343522
Leukemia 0.717527631
Colorectal Cancer 0.782147638
Cervical Cancer 0.912843014
Soft Tissue Cancer 0.36241519
Lung and Bronchus Cancer 0.340874577
Non-Hodgkin Lymphoma 0.252749423
Bone and Joint Cancer 0.244835711
Stomach Cancer 0.304733227

Age-adjusted death rates per 100,000. U.S., 2015–2019.

How Do Cancer Types Among AYAs Compare?

For comparison purposes, new cancer cases (incidence) and cancer deaths (mortality) are generally expressed as rates - that is, the number of new cases (or deaths) per 100,000 persons in the total population. Note that the total population varies depending on which group you are looking at, so, for example, the cancer incidence rate for females is the rate of new cancer cases per 100,000 females in the total population.

The table below gives the rate of new cases and deaths over the most recent five years of data and the five-year relative survival rate, representing the percent surviving their cancer for 5 years after diagnosis.

You can sort on any column by clicking the header to rank the case counts, deaths, incidence and mortality rates, relative survival in ascending or descending order.

Site Rate of New Cases (2015–2019) Death Rate (2015–2019) 5-Year Relative Survival (%) (2012–2018)
Bladder 0.6 0.0 88.9
Bone and Joint 0.9 0.3 71.3
Brain and Other Nervous System (ONS) 2.9 1.0 71.7
Breast 11.4 1.1 85.9
Cervix 6.5 0.9 80.1
Colon and Rectum 5.0 0.9 73.3
Hodgkin Lymphoma 3.4 0.1 96.4
Kidney and Renal Pelvis 2.5 0.2 88.9
Leukemia 3.6 0.9 72.0
Liver and Intrahepatic Bile Duct 0.5 0.2 36.7
Lung and Bronchus 1.0 0.4 50.0
Melanoma of the Skin 5.9 0.3 96.0
Myeloma 0.3 0.0 84.4
Non-Hodgkin Lymphoma 4.0 0.4 85.9
Oral Cavity and Pharynx 1.4 0.1 82.3
Ovary 3.0 0.4 81.1
Pancreas 0.7 0.2 54.7
Small Intestine 0.3 0.0 79.1
Soft Tissue 1.7 0.4 70.9
Stomach 0.9 0.3 34.0
Testis 11.5 0.4 95.3
Thyroid 11.9 0.0 99.8
Uterus 4.2 0.2 90.8
Rates of new cases are from SEER 22. Death rates are from the total U.S. Survival is from SEER 17.
Site Rate of New Cases (2015–2019) Death Rate (2015–2019) 5-Year Relative Survival (%) (2012–2018)
Bladder 0.4 0.0 82.1
Bone and Joint 0.7 0.2 74.8
Brain and Other Nervous System (ONS) 2.5 0.8 75.3
Breast 22.9 2.2 86.0
Cervix 6.5 0.9 80.1
Colon and Rectum 5.1 0.8 75.5
Hodgkin Lymphoma 3.4 0.1 97.1
Kidney and Renal Pelvis 2.1 0.1 91.4
Leukemia 3.0 0.7 72.7
Liver and Intrahepatic Bile Duct 0.4 0.2 42.3
Lung and Bronchus 1.0 0.3 55.7
Melanoma of the Skin 7.6 0.2 97.6
Myeloma 0.3 0.0 84.6
Non-Hodgkin Lymphoma 3.4 0.3 89.7
Oral Cavity and Pharynx 1.3 0.1 87.0
Ovary 3.0 0.4 81.1
Pancreas 0.7 0.2 65.3
Small Intestine 0.4 0.0 82.3
Soft Tissue 1.5 0.4 74.7
Stomach 0.9 0.3 41.0
Testis - - -
Thyroid 19.5 0.0 99.9
Uterus 4.2 0.2 90.8
Rates of new cases are from SEER 22. Death rates are from the total U.S. Survival is from SEER 17.
Site Rate of New Cases (2015–2019) Death Rate (2015–2019) 5-Year Relative Survival (%) (2012–2018)
Bladder 0.8 0.0 91.8
Bone and Joint 1.0 0.4 68.9
Brain and Other Nervous System (ONS) 3.2 1.2 69.1
Breast 0.1 0.0 74.9
Cervix - - -
Colon and Rectum 5.0 1.0 71.1
Hodgkin Lymphoma 3.5 0.1 95.7
Kidney and Renal Pelvis 2.9 0.2 87.1
Leukemia 4.2 1.1 71.5
Liver and Intrahepatic Bile Duct 0.6 0.3 33.1
Lung and Bronchus 0.9 0.4 44.1
Melanoma of the Skin 4.2 0.3 93.3
Myeloma 0.4 0.0 84.2
Non-Hodgkin Lymphoma 4.6 0.5 83.3
Oral Cavity and Pharynx 1.6 0.2 78.6
Ovary - - -
Pancreas 0.6 0.3 42.2
Small Intestine 0.3 0.0 75.9
Soft Tissue 1.8 0.5 67.8
Stomach 0.9 0.3 26.5
Testis 11.5 0.4 95.3
Thyroid 4.5 0.0 99.3
Uterus - - -
Rates of new cases are from SEER 22. Death rates are from the total U.S. Survival is from SEER 17.

Who Gets This Cancer?

The age-adjusted incidence rate among AYAs was 76.2 per 100,000 AYAs per year based on 2015–2019 cases.

Rates of New Cancers Among AYAs per 100,000 AYAs by Race/Ethnicity & Sex (ages 15–39)
Males
All Races 57.5
NH White 66.3
NH Black 45.1
NH Asian/Pacific Islander 41.6
NH American Indian/Alaska Native 60.8
Hispanic 49.8
Females
All Races 95.1
NH White 106.3
NH Black 80.7
NH Asian/Pacific Islander 77.2
NH American Indian/Alaska Native 106.9
Hispanic 83.9

SEER 22 2015–2019, Age-Adjusted

Who Dies From This Cancer?

The death rate was 8.8 per 100,000 AYAs per year based on 2015–2019 deaths.

Death Rates Among AYAs per 100,000 AYAs by Race/Ethnicity & Sex (Ages 15–39)
Males
All Races 8.2
NH White 8.3
NH Black 9.6
NH Asian/Pacific Islander 6.6
NH American Indian/Alaska Native 10.7
Hispanic 7.6
Females
All Races 9.4
NH White 9.1
NH Black 12.7
NH Asian/Pacific Islander 6.8
NH American Indian/Alaska Native 10.8
Hispanic 8.9

U.S. 2015–2019, Age-Adjusted

Trends in Rates

Changes Over Time

Keeping track of new cases, deaths, and survival over time (trends) can help scientists understand whether progress is being made and where additional research is needed to address challenges, such as improving screening or finding better treatments.

Interactive Statistics with SEER*Explorer

With SEER*Explorer, you can...
  • Create custom graphs and tables
  • Download data and images
  • Share links to results

SEER*Explorer is an interactive website that provides easy access to a wide range of SEER cancer statistics. It provides detailed statistics for a cancer site by gender, race, calendar year, age, and for a selected number of cancer sites, by stage and histology.

Explore Additional Cancer Statistics Among AYAs

More About Cancer

More Information

Here are some resources for learning more about cancer.

References

All statistics in this report are based on statistics from SEER and the Centers for Disease Control and Prevention's National Center for Health Statistics. Most can be found within SEER*Explorer.

Suggested Citation

All material in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.

SEER Cancer Stat Facts: Cancer Among Adolescents and Young Adults (AYAs). National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/statfacts/html/aya.html

These stat facts focus on population statistics that are based on the U.S. population. Because these statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. To see tailored statistics, browse SEER*Explorer. To see statistics for a specific state, go to the State Cancer Profiles.

The statistics presented in these stat facts are based on the most recent data available, most of which can be found in SEER*Explorer. In some cases, different year spans may be used.

Estimates of new cases and deaths for 2022 are projections made by the American Cancer Society (ACS), based on earlier reported data.

Cancer is a complex topic. There is a wide range of information available. These stat facts do not address causes, symptoms, diagnosis, treatment, follow-up care, or decision making, although links are provided to information in many of these areas.