Statistics at a Glance

At a Glance

Estimated New Cases in 2020 21,040

% of All New Cancer Cases 1.2%

Estimated Deaths in 2020 4,060

% of All Cancer Deaths 0.7%

5-Year
Relative Survival

86.1% 2010–2016
Year Rate of New Cases — SEER 9 Rate of New Cases — SEER 13 Death Rate — U.S. 5-Year Relative Survival — SEER 9
Observed Modeled Trend Observed Modeled Trend Observed Modeled Trend Observed Modeled Trend
1975 4.35 4.31 - - 1.39 1.43 68.32% 65.67%
1976 4.56 4.33 - - 1.43 1.44 65.36% 66.29%
1977 4.18 4.34 - - 1.46 1.44 69.31% 66.91%
1978 4.46 4.36 - - 1.43 1.45 69.32% 67.51%
1979 4.06 4.38 - - 1.47 1.46 65.70% 68.11%
1980 4.52 4.39 - - 1.50 1.46 69.69% 68.70%
1981 4.27 4.41 - - 1.48 1.47 63.44% 69.28%
1982 4.30 4.43 - - 1.49 1.47 65.30% 69.85%
1983 4.45 4.44 - - 1.50 1.48 69.09% 70.41%
1984 4.43 4.46 - - 1.45 1.49 71.96% 70.97%
1985 4.49 4.48 - - 1.53 1.49 75.26% 71.52%
1986 4.50 4.49 - - 1.51 1.50 70.68% 72.06%
1987 4.66 4.51 - - 1.45 1.51 71.32% 72.59%
1988 4.55 4.53 - - 1.49 1.51 76.86% 73.11%
1989 4.70 4.54 - - 1.56 1.55 71.03% 73.63%
1990 4.61 4.56 - - 1.59 1.59 77.11% 74.13%
1991 4.60 4.58 - - 1.66 1.63 71.16% 74.63%
1992 4.63 4.60 4.52 4.52 1.67 1.67 75.23% 75.12%
1993 4.46 4.61 4.32 4.46 1.71 1.71 76.76% 75.61%
1994 4.63 4.63 4.44 4.41 1.61 1.69 77.25% 76.08%
1995 4.56 4.65 4.39 4.36 1.69 1.67 78.57% 76.55%
1996 4.74 4.66 4.52 4.31 1.68 1.65 75.21% 77.01%
1997 4.52 4.53 4.22 4.25 1.58 1.62 73.98% 77.46%
1998 4.27 4.39 4.15 4.20 1.54 1.60 79.04% 78.48%
1999 4.19 4.27 3.95 4.15 1.64 1.58 74.67% 79.45%
2000 4.70 4.63 4.42 4.38 1.56 1.56 79.77% 80.39%
2001 5.36 5.03 4.87 4.61 1.56 1.54 81.82% 81.29%
2002 5.15 5.46 4.76 4.86 1.56 1.52 84.60% 82.15%
2003 5.41 5.49 5.01 5.13 1.55 1.50 82.94% 82.98%
2004 5.61 5.51 5.22 5.15 1.48 1.49 85.66% 83.77%
2005 5.48 5.54 5.03 5.17 1.47 1.47 86.42% 84.53%
2006 5.87 5.57 5.37 5.19 1.47 1.45 84.96% 85.26%
2007 5.46 5.59 5.17 5.22 1.43 1.43 89.79% 85.96%
2008 5.61 5.62 5.28 5.24 1.38 1.41 85.19% 86.62%
2009 5.52 5.64 5.26 5.26 1.40 1.39 87.06% 87.26%
2010 5.69 5.67 5.32 5.28 1.35 1.38 88.00% 87.87%
2011 5.64 5.56 5.16 5.13 1.36 1.36 89.08% 88.45%
2012 5.39 5.46 4.83 4.99 1.33 1.34 89.75% 89.00%
2013 5.28 5.36 4.76 4.85 1.31 1.28 - 89.53%
2014 5.41 5.26 4.82 4.71 1.25 1.23 - 90.04%
2015 5.21 5.16 4.68 4.57 1.11 1.18 - 90.52%
2016 4.89 5.06 4.32 4.44 1.13 1.13 - 90.98%
2017 5.02 4.97 4.36 4.32 1.11 1.08 - 91.42%

New cases come from SEER 13. Deaths come from U.S. Mortality.
All Races, Both Sexes. Rates are Age-Adjusted.
Modeled trend lines were calculated from the underlying rates using the Joinpoint Trend Analysis Software.

New cases are also referred to as incident cases in other publications. Rates of new cases are also referred to as incidence rates.


Rate of New Cases and Deaths per 100,000: The rate of new cases of chronic lymphocytic leukemia was 5.0 per 100,000 men and women per year. The death rate was 1.2 per 100,000 men and women per year. These rates are age-adjusted and based on 2013–2017 cases and deaths.

Lifetime Risk of Developing Cancer: Approximately 0.6 percent of men and women will be diagnosed with chronic lymphocytic leukemia at some point during their lifetime, based on 2015–2017 data.

Prevalence of This Cancer: In 2017, there were an estimated 186,422 people living with chronic lymphocytic leukemia in the United States.

Did You Know? Video Series

Survival Statistics

How Many People Survive 5 Years Or More after Being Diagnosed with Chronic Lymphocytic Leukemia?

Relative survival statistics compare the survival of patients diagnosed with cancer with the survival of people in the general population who are the same age, race, and sex and who have not been diagnosed with cancer. Because survival statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. No two patients are entirely alike, and treatment and responses to treatment can vary greatly.

86.1%

5-Year
Relative Survival

86.1%

Based on data from SEER 18 2010–2016. Gray figures represent those who have died from chronic lymphocytic leukemia. Green figures represent those who have survived 5 years or more.

Additional Information

New Cases and Deaths

How Common Is This Cancer?

Rank Common Types of Cancer Estimated New
Cases 2020
Estimated
Deaths 2020
1. Breast Cancer (Female) 276,480 42,170
2. Lung and Bronchus Cancer 228,820 135,720
3. Prostate Cancer 191,930 33,330
4. Colorectal Cancer 147,950 53,200
5. Melanoma of the Skin 100,350 6,850
6. Bladder Cancer 81,400 17,980
7. Non-Hodgkin Lymphoma 77,240 19,940
8. Kidney and Renal Pelvis Cancer 73,750 14,830
9. Uterine Cancer 65,620 12,590
10. Leukemia 60,530 23,100
- - -
Chronic Lymphocytic Leukemia 21,040 4,060

Chronic lymphocytic leukemia represents 1.2% of all new cancer cases in the U.S.

1.2%

In 2020, it is estimated that there will be 21,040 new cases of chronic lymphocytic leukemia and an estimated 4,060 people will die of this disease.

Who Gets This Cancer?

Chronic lymphocytic leukemia is more common in adults and more common among men than women, particularly white men. The rate of new cases of chronic lymphocytic leukemia was 5.0 per 100,000 men and women per year based on 2013–2017 cases, age-adjusted.

Rate of New Cases per 100,000 Persons by Race/Ethnicity & Sex: Chronic Lymphocytic Leukemia (CLL)
Males
All Races 6.8
White 7.3
Black 4.8
Asian/Pacific Islander 1.6
American Indian/Alaska Native 2.8
Hispanic 2.8
Non-Hispanic 7.3
Females
All Races 3.5
White 3.9
Black 2.4
Asian/Pacific Islander 0.8
American Indian/Alaska Native 0.9
Hispanic 1.7
Non-Hispanic 3.8

SEER 21 2013–2017, Age-Adjusted

Percent of New Cases by Age Group: Chronic Lymphocytic Leukemia
Age Range Percent of New Cases
<20 0.0%
20–34 0.3%
35–44 1.5%
45–54 8.6%
55–64 22.6%
65–74 30.1%
75–84 23.8%
>84 13.1%

Chronic lymphocytic leukemia is most frequently diagnosed among people aged 65–74.

Median Age
At Diagnosis

70

SEER 21 2013–2017, All Races, Both Sexes

Who Dies From This Cancer?

Death rates from chronic lymphocytic leukemia are higher among older adults, or those 75 and older. People with leukemia have many treatment options, and treatment for leukemia can often control the disease and its symptoms. The death rate was 1.2 per 100,000 men and women per year based on 2013–2017 deaths, age-adjusted.

Death Rate per 100,000 Persons by Race/Ethnicity & Sex: Chronic Lymphocytic Leukemia (CLL)
Males
All Races 1.7
White 1.8
Black 1.5
Asian/Pacific Islander 0.4
American Indian/Alaska Native 0.5
Hispanic 0.6
Non-Hispanic 1.8
Females
All Races 0.8
White 0.8
Black 0.7
Asian/Pacific Islander 0.1
American Indian/Alaska Native Not Shown, <16 cases
Hispanic 0.3
Non-Hispanic 0.8

U.S. 2013–2017, Age-Adjusted

Percent of Deaths by Age Group: Chronic Lymphocytic Leukemia
Age Range Percent of Deaths
<20 0.0%
20–34 0.1%
35–44 0.3%
45–54 1.8%
55–64 8.5%
65–74 19.3%
75–84 32.8%
>84 37.2%

The percent of chronic lymphocytic leukemia deaths is highest among people aged 85+.

Median Age
At Death

81

U.S. 2013–2017, All Races, Both Sexes

Trends in Rates

Changes Over Time

Keeping track of new cases, deaths, and survival over time (trends) can help scientists understand whether progress is being made and where additional research is needed to address challenges, such as improving screening or finding better treatments.

Using statistical models for analysis, age-adjusted rates for new chronic lymphocytic leukemia cases have been falling on average 1.4% each year over the last 10 years. Age-adjusted death rates have been falling on average 2.9% each year over 2008–2017. 5-year relative survival trends are shown below.

More About This Cancer

Cancer and the Blood

Figure: Blood Cells Maturing from Stem Cells

Figure: Stem cells maturing into one of three types of mature blood cells: red blood cells, platelets, and white blood cells. Precursor cells are also shown: stem cells, myeloid blasts, lymphoid stem cells, and lymphoid blasts.

Leukemia is cancer that starts in the tissue that forms blood. Most blood cells develop from cells in the bone marrow called stem cells. In a person with leukemia, the bone marrow makes abnormal white blood cells. The abnormal cells are leukemia cells. Unlike normal blood cells, leukemia cells don't die when they should. They may crowd out normal white blood cells, red blood cells, and platelets. This makes it hard for normal blood cells to do their work. The four main types of leukemia are:

There is no standard staging system for leukemia. The disease is described as untreated, in remission, or recurrent.

p>Additional Information

More Information

Here are some resources for learning more about leukemia.

References

All statistics in this report are based on statistics from SEER and the Centers for Disease Control and Prevention's National Center for Health Statistics. Most can be found within:

Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975–2017, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2017/, based on November 2019 SEER data submission, posted to the SEER web site, April 2020.

Suggested Citation

All material in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.

SEER Cancer Stat Facts: Chronic Lymphocytic Leukemia. National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/statfacts/html/clyl.html

These stat facts focus on population statistics that are based on the U.S. population. Because these statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. To see tailored statistics, browse the SEER Cancer Statistics Review. To see statistics for a specific state, go to the State Cancer Profiles.

The statistics presented in these stat facts are based on the most recent data available, most of which can be found in the SEER Cancer Statistics Review. In some cases, different year spans may be used. Estimates for the current year are based on past data.

Cancer is a complex topic. There is a wide range of information available. These stat facts do not address causes, symptoms, diagnosis, treatment, follow-up care, or decision making, although links are provided to information in many of these areas.