Search Database ICD-O-3 Code Lists

Name

Myeloid leukemia, NOS

ICD-O-3 Morphology

9860/3: Myeloid leukemia, NOS
Effective 2001 and later

Reportable

for cases diagnosed 1978 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Coding Manual: Hematopoietic Coding Manual (PDF)

Abstractor Notes

Myeloid leukemia, NOS is not included in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B23)

Myeloid leukemia, NOS is a generic neoplasm description. DCO cases or path report only cases may stay in this classification.

In most cases, NOS histology is only the provisional diagnosis; the physician will run further diagnostic procedures and look for various clinical presentations to identify a more specific neoplasm. Further review of the medical record should be done to look for the tests listed as definitive diagnosis. If no information is found in the medical record, follow-back to the attending physician should be done.

More specific myeloid leukemias include
1. Acute basophilic leukemia (9870/3)
2. Acute erythroid leukemia (9840/3)
3. Acute megakaryoblastic leukemia (9910/3)
4. Acute myeloid leukemia, NOS (9861/3)
5. Acute myeloid leukemia, myelodysplasia-related (9895/3)
6. Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 (9911/3)
7. Acute myeloid leukemia with BCR-ABL1 (9912/3) (2021+) (See 9861/3 prior to 2021)
8. Acute myeloid leukemia with biallelic mutation of CEBPA (9878/3) (2021+) (See 9861/3 prior to 2021)
9. Acute myeloid leukemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM (9869/3)
10. Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 (9871/3)
11. Acute myeloid leukemia with maturation (9874/3)
12. Acute myeloid leukemia with minimal differentiation (9872/3)
13. Acute myeloid leukemia with mutated NPM1 (9877/3) (2021+) (See 9861/3 prior to 2021)
14. Acute myeloid leukemia with mutated RUNX1 (9879/3) (2021+) (See 9861/3 prior to 2021)
15. Acute myeloid leukemia with myelodysplasia-related changes (9895/3)
16. Acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214 (9865/3)
17. Acute myeloid leukemia, t(8;21)(q22;q22.1); RUNX1-RUNX1T1 (9896/3)
18.Acute myeloid leukemia with t(9;11)(p21.3;q23.3); KMT2A-MLLT3 (9897/3)
19. Acute myeloid leukemia without maturation (9873/3)
20. Acute myelomonocytic leukemia (9867/3)
21. Acute monocytic leukemia (9891/3)
22. Myeloid leukemia associated with Down syndrome (9898/3)

When a more specific diagnosis is identified, the histology should be changed to the more specific neoplasm name and code. See the histology tables for more information on NOS and more specific histologies.

Diagnostic Confirmation

This is a histology for which the Definitive Diagnostic Method does not include Genetics Data or Immunophenotyping, thus Diagnostic Confirmation should never be 3. If genetics and/or immunophenotyping are available, re-review to see if a more specific neoplasm can be coded.

Module Rule

None

Alternate Names

Aleukemic granulocytic leukemia [OBS]
Aleukemic monocytic leukemia [OBS]
Aleukemic myelogenous leukemia [OBS]
Aleukemic myeloid leukemia [OBS]
Chronic monocytic leukemia [OBS]
Eosinophilic leukemia
Granulocytic leukemia, NOS
Monocytic leukemia, NOS
Myelocytic leukemia, NOS
Myelogenous leukemia, NOS
Myeloid stem cell disorder, NOS
Myeloid stem cell neoplasm, NOS
Myelomonocytic leukemia [OBS] see codes 9945/3 or 9967/3
Non-lymphocytic leukemia, NOS
Subacute granulocytic leukemia [OBS]
Subacute monocytic leukemia [OBS]
Subacute myelogenous leukemia [OBS]
Subacute myeloid leukemia [OBS]

Definition

General term for non-specific myeloid leukemia (unknown if chronic or acute) in which cell typing has not been done, or the information is not available.

Definitive Diagnostic Methods

Clinical diagnosis
Histologic confirmation

Genetics Data

None

Immunophenotyping

None

Treatments

None

Transformations to

There are no known transformations

Transformations from

There are no known transformations

Same Primaries

Corresponding ICD-10 Codes (Cause of Death codes only)

C92.2 Subacute myeloid leukemia
C92.9 Myeloid leukemia, unspecified
C93.2 Subacute monocytic leukemia
C93.7 Other monocytic leukemia
C93.9 Monocytic leukemia, unspecified

Corresponding ICD-10-CM Codes (U.S. only)

C92.9 Myeloid leukemia, unspecified (effective October 01, 2015 - September 30, 2024)
C92.90 Myeloid leukemia, unspecified not having achieved remission (effective October 01, 2024)
C92.91 Myeloid leukemia, unspecified, in remission (effective October 01, 2024)
C92.92 Myeloid leukemia, unspecified, in relapse (effective October 01, 2024)
C93.9 Monocytic leukemia, unspecified (effective October 01, 2015 - September 30, 2024)
C93.90 Monocytic leukemia, unspecified not having achieved remission (effective October 01, 2024)
C93.91 Monocytic leukemia, unspecified, in remission (effective October 01, 2024)
C93.92 Monocytic leukemia, unspecified, in relapse (effective October 01, 2024)
C93.Z Other monocytic leukemia (effective October 01, 2015 - September 30, 2024)
C93.Z0 Other monocytic leukemia not having achieved remission (effective October 01, 2024)
C93.Z1 Other monocytic leukemia, in remission (effective October 01, 2024)
C93.Z2 Other monocytic leukemia, in relapse (effective October 01, 2024)

Signs and Symptoms

Bone or joint pain
Easy bruising or bleeding
Eczema-like skin rash
Fatigue
Fever
Night sweats
Pain or feeling of fullness below the ribs
Painless lumps
Petechiae
Shortness of breath
Weakness

Diagnostic Exams

Bone marrow aspiration and biopsy
CT (CAT) Scan
Cytogenetic analysis
Flow cytometry
Immunophenotyping
Lumbar puncture
Molecular analysis
Peripheral blood smear
Physical exam and history

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

International Classification of Diseases for Oncology, 3rd edition (including revisions). Geneva: World Health Organization, 2001, 2011, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
Glossary