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Name
Myeloid leukemia, NOS
Effective
1978 - 1991
Effective
1992 - 2000
Reportable
for cases diagnosed
1978 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)
Coding Manual:
Hematopoietic Coding Manual (PDF)
Abstractor Notes
Myeloid leukemia, NOS is a generic neoplasm description. DCO cases or path report only cases may stay in this classification.
In most cases, NOS histology is only the provisional diagnosis; the physician will run further diagnostic procedures and look for various clinical presentations to identify a more specific neoplasm. Further review of the medical record should be done to look for the tests listed as definitive diagnosis. If no information is found in the medical record, follow-back to the attending physician should be done.
More specific myeloid leukemias include:
1. Acute myeloid leukemia, NOS (9861/3)
2. Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 (9911/3)
3. Acute myeloid leukemia with BCR-ABL1 (9912/3) (2021)+
4. Acute myeloid leukemia with biallelic mutation of CEBPA (9878/3) (2021+)
5. Acute myeloid leukemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM (9869/3)
6. Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 (9871/3)
7. Acute myeloid leukemia with maturation (9874/3)
8. Acute myeloid leukemia with minimal differentiation (9872/3)
9. Acute myeloid leukemia with mutated NPM1 (9877/3) (2021+)
10. Acute myeloid leukemia with mutated RUNX1 (9879/3) (2021+)
11. Acute myeloid leukemia with myelodysplasia-related changes (9895/3)
12. Acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214 (9865/3)
13. Acute myeloid leukemia, t(8;21)(q22;q22.1); RUNX1-RUNX1T1 (9896/3)
14.Acute myeloid leukemia with t(9;11)(p21.3;q23.3); KMT2A-MLLT3 (9897/3)
15. Acute myeloid leukemia without maturation (9873/3)
16. Myeloid leukemia associated with Down syndrome (9898/3)
17. Myeloid/lymphoid neoplasms with PDGFRB rearrangement (9966/3)
When a more specific diagnosis is identified, the histology should be changed to the more specific neoplasm name and code. See the histology tables for more information on NOS and more specific histologies.
In most cases, NOS histology is only the provisional diagnosis; the physician will run further diagnostic procedures and look for various clinical presentations to identify a more specific neoplasm. Further review of the medical record should be done to look for the tests listed as definitive diagnosis. If no information is found in the medical record, follow-back to the attending physician should be done.
More specific myeloid leukemias include:
1. Acute myeloid leukemia, NOS (9861/3)
2. Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 (9911/3)
3. Acute myeloid leukemia with BCR-ABL1 (9912/3) (2021)+
4. Acute myeloid leukemia with biallelic mutation of CEBPA (9878/3) (2021+)
5. Acute myeloid leukemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM (9869/3)
6. Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 (9871/3)
7. Acute myeloid leukemia with maturation (9874/3)
8. Acute myeloid leukemia with minimal differentiation (9872/3)
9. Acute myeloid leukemia with mutated NPM1 (9877/3) (2021+)
10. Acute myeloid leukemia with mutated RUNX1 (9879/3) (2021+)
11. Acute myeloid leukemia with myelodysplasia-related changes (9895/3)
12. Acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214 (9865/3)
13. Acute myeloid leukemia, t(8;21)(q22;q22.1); RUNX1-RUNX1T1 (9896/3)
14.Acute myeloid leukemia with t(9;11)(p21.3;q23.3); KMT2A-MLLT3 (9897/3)
15. Acute myeloid leukemia without maturation (9873/3)
16. Myeloid leukemia associated with Down syndrome (9898/3)
17. Myeloid/lymphoid neoplasms with PDGFRB rearrangement (9966/3)
When a more specific diagnosis is identified, the histology should be changed to the more specific neoplasm name and code. See the histology tables for more information on NOS and more specific histologies.
Diagnostic Confirmation
This is a histology for which the Definitive Diagnostic Method does not include Genetics Data or Immunophenotyping, thus Diagnostic Confirmation should never be 3. If genetics and/or immunophenotyping are available, re-review to see if a more specific neoplasm can be coded.
Grade
Not Applicable
Module Rule
None
Alternate Names
Aleukemic granulocytic leukemia [OBS]
Aleukemic myelogenous leukemia [OBS]
Eosinophilic leukemia
Granulocytic leukemia, NOS
Monocytic leukemia, NOS
Myelocytic leukemia, NOS
Myelogenous leukemia, NOS [OBS]
Non-lymphocytic leukemia, NOS
Subacute granulocytic leukemia [OBS]
Subacute myelogenous leukemia [OBS]
Definition
Definitive Diagnostic Methods
Bone marrow biopsy
Peripheral blood smear
Genetics Data
None
Immunophenotyping
None
Treatments
None
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Same Primaries
Corresponding ICD-9 Codes
205.9 Unspecified myeloid leukemia
205.2 Subacute myeloid leukemia
206.2 Subacute monocytic leukemia
206.8 Other monocytic leukemia
206.9 Unspecified monocytic leukemia
Corresponding ICD-10 Codes
C92.2 Subacute myeloid leukemia
C92.9 Myeloid leukemia, unspecified
C93.2 Subacute monocytic leukemia
C93.7 Other monocytic leukemia
C93.9 Monocytic leukemia, unspecified
Corresponding ICD-10-CM Codes (U.S. only)
C92.9 Myeloid leukemia, unspecified (effective October 01, 2015)
C93.9 Monocytic leukemia, unspecified (effective October 01, 2015)
C93.Z Other monocytic leukemia (effective October 01, 2015)
Signs and Symptoms
None
Diagnostic Exams
None
Progression and Transformation
None
Epidemiology and Mortality
None
Sources
International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
