The installation program(s) for SEER*Stat are provided below. All new software releases will be posted here and will include the version number in the filename. SEER*Stat's title bar includes the version number so that you can see if you are using the latest version.
The SEER*Stat software has an auto-update feature. The software can be configured to automatically upgrade with the SEER*Stat release or to delay the update for a couple weeks after the release. See Auto-updating in SEER*Stat for more information.
Current SEER*Stat users may sign up for e-mail updates to receive advanced notice of software releases.
In most cases to use SEER*Stat, you must have access to the SEER Research Data. The installation program provided here does not include or provide access to these data. If you have not done so already, please follow the steps to Access the SEER Research Data.
SEER*Stat Readme File
----------------- SEER*Stat 8.3.4 ----------------- The SEER*Stat statistical software provides a convenient, intuitive mechanism for the analysis of SEER and other cancer-related databases. It is a powerful PC tool to view individual cancer records and to produce the statistics listed below. These statistics are useful when studying the impact of cancer on a population. Frequency and Rate Statistics - Frequencies - Row and column percentages - Crude (non-adjusted) rates with standard errors and confidence intervals - Age-adjusted rates with standard errors and confidence intervals - Incidence-based mortality rates - Rate ratios for significance testing Trends Over Time (based on frequencies and rates) - Percent changes (PC) - Annual percent changes (APC) with confidence intervals - Comparison of APCs with zero - Comparison of two APCs with one another Survival Statistics - Observed survival - Net survival (absence of other causes of death) - Relative survival - Cause-specific survival - Crude probability of death (presence of other causes of death) - Using expected survival - Using cause of death - Option to adjust for heterogeneity in withdrawal when using expected survival - Comparison of two survival curves (Z-statistic) - Conditional survival - a survival rate conditioned on having survived x years (for example, a 10-year rate for individuals having already survived 5 years) - Actuarial and Kaplan-Meier methods - Period survival for all survival session methods Limited-Duration Prevalence Statistics - Prevalence counts - Crude (non-adjusted) percents - Age-adjusted percents - Profile survival for limited-duration prevalence (future) Multiple Primary - Standardized Incidence Ratio Statistics Comparison of cancer incidence in a defined cohort of persons previously diagnosed with cancer to cancer incidence in the general population. In other words, The MP-SIR session allows you to define a cohort of people based on first cancer diagnosis (exposure) and to follow them through time to compare their subsequent cancer experience (observed events) to population based expected values. Case Listings - The values stored in the database for individual records are presented in a table. - You choose the variables displayed and select the records to be included in the table. -------- FEATURES -------- - Easy to use interface - Comprehensive help system - Ability to select/exclude cases using multiple primary criteria (i.e., SEER*Stat realizes a person can have more than one tumor) - Handles complex selection/subset statements with support for full Boolean logic - Multi-dimensional matrices for reporting results - Support for copying and pasting cancer records and statistics into spreadsheet or charting/graphing packages - Ability to export records and statistics to a generic data file for input by other statistical systems such as SAS - Print preview - User Profiles for managing workflow --------------------------- CLIENT-SERVER CONFIGURATION --------------------------- With this configuration, all data are stored in a centralized location at the SEER Program and calculations are performed on SEER's dedicated hardware. If you utilize this mechanism, you do not need to maintain the SEER data on your local computer system. Each time you execute an analysis, the parameters of your request will be transferred over the Internet from your computer to the SEER*Stat server. Once the calculations are complete, the results will be transferred back to your computer. A high speed Internet connection is required for this configuration. ------------------- SYSTEM REQUIREMENTS ------------------- - Pentium-based PC - 32-bit or 64-bit Microsoft Windows Operating System (Windows 7, Vista, XP, 2000, NT, 98, 95, etc.) - 800 x 600 or greater monitor resolution - Microsoft Internet Explorer 4.0+ for viewing help - 32 MBs application RAM - Approximately 16 MBs disk space - High speed Internet connection (not a dial-up modem based) if using the client-server configuration ------------ INSTALLATION ------------ To install from the SEER Research Data DVD: - Insert the DVD into the drive - From the Start menu, choose Run...; type [dvd-drive]:\SEER_1973_2012_SEERSTAT\install\setup.exe - Follow the instructions on your screen To install using the installation program from the Internet: - Download the installation program from http://seer.cancer.gov/seerstat/software - Within Windows, double-click on the downloaded file - Follow the instructions on your screen Unless the data location is changed from the default with the File, Preferences... dialog, the DVD must be located in the drive or you must have an account within the client-server configuration to execute SEER*Stat. -------------------------------- LOCAL AREA NETWORK INSTALLATIONS -------------------------------- A single copy of the SEER*Stat executable and data can be placed on a network for multiple persons to utilize. This configuration is highly recommended because updates to SEER*Stat can be performed on the single network installation instead of modifying each user's desktop PC. Copy the contents of the [dvd-drive]:\SEER_1973_2012_SEERSTAT\bin directory (seerstat.exe and seerstat.chm) from the DVD to a location on the network accessible by all users. Suppose this location is called "\\fileserv1\SEERStat". Then copy the [dvd-drive]:\SEER_1973_2012_SEERSTAT\data directory and all its sub-directories from the DVD to this location. This will yield a directory on your network called "\\fileserv1\SEERStat\data". On each user's desktop PC, create a Windows shortcut to "\\fileserv1\SEERStat\seerstat.exe". The first time each user executes SEER*Stat, it will display the Data Locations and the default User-Defined Variables Location (UVL). The default Data location is "\\fileserv1\SEERStat\data". The UVL varies by the version of Microsoft Windows. If a network installation is configured, use must be confined to persons that have completed the SEER Research Data Agreement. If others wish to make use of the system, each must complete the SEER Program's Research Data Agreement available on the SEER Web page at the following address. http://seer.cancer.gov/dataagreements/seer.pdf ------------------------------- REMOVING PREVIOUS INSTALLATIONS ------------------------------- Existing versions of SEER*Stat do not need to be removed from your system prior to installing this newer version. This version may NOT allow you to analyze data contained on CDs/DVDs earlier than SEER*Stat 6.3.6. If you need to analyze data from earlier CDs/DVDs, you may not want to overwrite an earlier installation with this version. If you wish to completely remove an earlier version prior to installing this current version, use the Add/Remove Programs icon in the Windows Control Panel. ---------------- REVISION HISTORY ---------------- 3/22/2017 - Version 8.3.4 1. Fixed bug that disabled Case Listing Export menu option when the Font menu option is disabled because of missing printer. 2. Updated the warning message when user attempts to modify/save a referent rate matrix. 1/23/2017 - Version 8.3.3 1. Fixed bug in MP-SIR calculation when output is case listing and merged variables are included in the table. 2. Fixed bug in Survival calculation to prevent invalid references to summary table cells. 3. Fixed bug in client-server login, when server data location is not first for the current profile. 4. Fixed bug in Rate calculation that caused integer overflow when calculating memory requirement for very large number of cells. 5. Upgraded handling of case suppression in calculations to include suppression of zero counts. 6. Left-Truncated Life Tables calculations were updated regarding the exact starting age for cumulative calculations when using the Modified Product Limit stability criteria. If the Modified Product Limit is enabled, SEER*Stat now only looks at the beginning of each age (e.g. 40 years and 0 months) rather than the monthly ages (e.g. 40 years and 6 months). Once the number alive is >= the computed R, SEER*Stat will start to compute cumulative values until there are no alive cases in the cohort or the maximum age is reached. Previously, if the alive cases reached the R value in the middle of an age, SEER*Stat would start the calculations at the start of the next age. 7. MP-SIR referent rates created from mortality databases are not usable with SIR databases, and incidence referent rates are not usable with SMR databases. 8. Exporting a Rate matrix as MP-SIR Rates will no longer be allowed for Incidence-Based Mortality databases. 9. Added a button to the matrix export dialog for easily updating the settings for creation of CSV (Excel) output files. 10. Added warning message to Left-truncated Life Tables session for potential changes in system defaults when a database is selected. 11. Fixed warning for invalid case listing variables in a survival session on database change. 12. Updated warning message for switching from summary files in order to produce exclusion counts. 13. Added a warning message for duplicate database IDs found in databases that exist in more than one data location. 14. Upgraded variable export dialog to allow appending to an existing export (.fmx) file. 15. Upgraded the OpenSSL encryption software to version 1.0.2h. 04/14/2016 - Version 8.3.2 1. Fixed bug in Rate calculation subset, when Related File is used for Population selection. 04/01/2016 - Version 8.3.1 1. Upgraded Case Exclusion Report for Frequency, Case listing and Prevalence: Fixed Person Selection and Age at Prevalence counts. 2. Added support for system-supplied variable definitions in local user-created databases. 3. Upgraded the OpenSSL encryption software to version 1.0.2f. 02/22/2016 - Version 8.3.0 1. Case Exclusion counts added to Frequency, Rate, Prevalence, and Case Listing matrices. 2. The survival calculation was modified such that if everyone exits in a given interval and there were one or more censored cases, then the survival estimate is not calculated. 3. Z-Test statistics can now be displayed in the summary pages of survival results. 4. Fixed Survival export for Pohar Perme: added new statistic names. 5. Created new exclusion statement and warning in the Survival session for cases with Year of Diagnosis earlier than the expected rate table years. This feature is implemented in specific expected survival tables. 6. Added new checkbox to display all calculated statistics by default for several sessions. 7. Added a new Find feature to the Data tab, for finding databases that match user supplied strings. 8. Upgraded the Variable Find dialog. Added a separate listbox for variable names with hits, and allowing multiple matching labels. 9. Allow Year variable to be included in a merged variable when doing Trend analysis. 10. Added a new dialog to display the underlying selection statements for each of the standard selections on the session's selection tab. Added a "view statements" link to the new dialog on the selection tab. 11. Moved the Export as Text menu option for sessions from the File menu to the Session menu. 12. Fixed the linked database selection dialog to remove superfluous session-save button. 13. Fixed bug in search edit dialog encountered when selected lines skip over other lines (introduced in version 8.2.0). 14. Fixed Expected Rates cache to include index files when available. 15. Fixed download of Expected Rates from one server to be uploaded to a different server when executing session. 16. Changed the word 'implicit' to 'composite' in delay adjusted matrix. 17. Upgraded Invalid Variables dialog to fix labels that are converted from binary values when a selection has no other invalid lines. 18. Fixed paste from clipboard feature in the Search Edit dialog to display error message when search line is too long. 19. Fixed bug in person selection triggered when person's records that are included in the database are not contiguous in the file. 20. Fixed computation of number of cells resulting in a Left Truncated Life Tables session to detect jobs that are too large. 21. Fixed calculation of percent progress in ZD search function to handle large number of records. Fixed Client-Server progress updates to avoid percent values that are out of range (negative). 22. Upgraded the OpenSLL encryption software to version 1.0.2d. 04/08/2015 - Version 8.2.1 1. Fixed the matrix export for Frequency session to show count statistic when there are column variables and no percentages. This problem was introduced in version 8.2.0. 03/31/2015 - Version 8.2.0 1. Added the ability to produce both delay and non-delay adjusted statistics in a single analysis in the rate and frequency sessions. Delay adjustment only available in specific databases. 2. Fixed the Crude Probability of Death Using Cause of Death survival calculation to correctly handle exclusion of cases where the patient died with zero survival time due to other causes of death. 3. Added support of large expected rate tables for use in survival session. This includes tables by state-county. 4. Expected Rate data from the server now cached separately from ancillary files in the user's cache. For local use they are downloaded on session execute. 5. Matrix columns have been reordered for Rate sessions with Rate Ratios. 6. Year variables are no longer allowed in the table for Trend analyses. 7. A new button to save the session as text has been added to the dialog for selecting an alternative database when the session's original database is no longer available. The matrix menu option to export the session as text has been dropped. 02/02/2015 - Version 8.1.6 1. Added functionality to allow user to reset password. 2. Upgraded to the latest version of OpenSSL encryption software with the 'heartbleed' bug fixed. Added security enhancements to the server. 3. Frequency: Added support for adjusting precision in percentages. 4. Fixed minor bug in the calculation engine's casting syntax that now detects and stops jobs with excessive memory requirements. 5. Added support for multi-paged exclusion report in Survival, MP-SIR, and Left-Truncated Life Tables. 6. Survival: Allow single values as well as ranges in special interval. 7. Survival: Added Age Standardization Contributors matrix page. 8. Survival: Upgraded Pohar Perme calculation for 'Alpha' release. 9. Fix initialization of conjunction in the search/selection dialog. 10. Modified subset display controls on all Selection Tabs to prevent wrap-around of search statement lines. 11. Matrix Export: Added "NA" as one of the ways to represent missing data. This is useful when reading data into R programs. Also added a new option to omit creation of dictionary file when executing from the command line. 03/28/2014 - Version 8.1.5 1. Survival: A few cosmetic changes were made to the Parameters tab. 2. The Help system has been updated to include recent changes. 03/18/2014 - Version 8.1.4 1. New Expected Survival Tables available with November 2013 submission. The new life tables have data through 2009, but the more significant change is the fact that they only have ages through 99. This will result in the exclusion of all patients with an age of diagnosis of 100+. The new tables are used as the default for November 2013 data. 2. Survival: A new checkbox was added to the Parameters tab to censor cases when attained age exceeds the maximum age in the expected rate table. A new default expected rate table with maximum age of 99 years was provided. When using this table, cases with age at diagnosis of 100 or greater will be removed from analysis. 3. MP-SIR: There was the potential to have cases in the Case Listing which had negative person time when an exit point was specified (early exit or exit at event in rate file, etc.). These people are now removed from those types of runs. Exclusion counts have been updated to account for these excluded individuals. 4. MP-SIR Tables: If Attained Calendar Year was a table dimension and a latency period was specified, the count of the number of people could have been off. This would also affect other statistics that use the number of people such as: mean person years at risk, mean age at exposure, and mean date of exposure. The other information tallied in the table (person time, observed, expected, etc.. ) was being calculated correctly. 5. A warning message was added at the start of Profile|Preferences to indicate that data locations cannot be changed when a session is open. 01/16/2014 - Version 8.1.3 1. Left-Truncated Life Tables session is no longer a beta feature. 2. Added ability to include Standard Populations in the output for a Rate session. 3. Added functionality for Delay Adjusting when using certain databases in Rate or Frequency sessions. 4. Merged variables can now be used in defining groupings for other merged variables. Merged variables are also allowed in case listings generated by Survival, MP-SIR and Left-Truncated Life Tables sessions. 5. Fixed bug in setting of page types for printing of Left-Truncated Life Tables matrix. 6. Upgraded functions for estimating number of matrix pages for Survival and Left-Truncated Life Tables sessions. 7. Survival: Added more case count exclusion criteria when the “All tumors matching selection criteria” multiple primary option is specified. Life Pages were updated to contain additional information in footnotes. 09/09/2013 - Version 8.1.2 1. Changed the writing of file associations in the registry from the HKEY_LOCAL_MACHINE hive to the HKEY_CURRENT_USER hive to ensure that updates will be performed without Admin privileges. 2. Fixed bug in MP-SIR case listing so that each patient would have a record with a reason for exit and person time. 08/26/2013 - Version 8.1.1 1. Survival and Left-Truncated Life Tables case listings now support unlimited number of output fields. A new dimension is added to the table tab for Case Listing Only variables. The Parameters and Table tabs have been switched in the survival tab order. 2. Survival - added person shading to case listing when the MP option "All Cases Matching Criteria" is selected. 3. Survival - Removed case-sensitivity when validating the names of COD variables. 4. Survival now disallows age standardizing when the age standardizing variable has only one grouping. 5. Left-Truncated Life Tables beta release. Added stability criteria. 6. Fixed bug that allowed duplicate variable names in the dialog for resolving invalid session variables on load or database change. 7. Variable Find dialog now returns found value to the search dialog and selects it there. 8. Upgraded client-server data encryption software to latest version. 04/12/2013 - Version 8.0.4 1. Survival case listing new fields added, change in expected. New fields are age and year of last interval for the patient. The interval expected survival included in the matrix is directly from the expected survival table used. Previously, it was adjusted based on interval length. e.g. Twelfth root was taken for monthly survival. 2. Survival - fixed bug that prevented new session from opening when pre-calculated duration variables are not available. Only applicable to those using 8.0.3 (not released on public ports). 3. Allow case listing matrix with no records to be copied to the clipboard (field names only). 03/15/2013 - Version 8.0.3 1. Survival calculation can now be based on pre-calculated survival duration variables or on dates (begin and end dates). The Pre-calculated survival duration option will be the default for SEER databases starting with the November 2012 submission. The pre-calculated survival variables in the SEER data (Nov 2012+) have been calculated using complete dates rather than just month and year. 2. Survival session - the Case Listing option has been removed from the session dropdown menu and is now available on the Parameters tab along with the other display options. 3. New matrix menu option added to extract the source session as a text file without having to open it in the interface. In-house beta version only: 4. The matrix export utility was implemented for Left-Truncated Life Tables. 02/19/2013 - Version 8.0.2 1. MP-SIR – there was a problem that occurred only when using early criteria. The problem was limited to the case listing and frequency statistics and did not impact the standard SIR analyses. Highlighting in case listing and record counts when producing frequencies were affected. 2. Survival session - sessions would not execute when relative conditional survival statistics were requested and included in the cumulative summary pages. 3. Survival session – survival case listings sessions would not execute if the new multiple primary selection option was set to “All Tumors Matching Selection Criteria”. This did not impact standard survival analyses. 4. Limited-duration prevalence – sessions would not execute only when the multiple primary selection option was set to “All Tumors Matching Selection Criteria”, age-adjusted prevalence was being calculated, and the age variable for the age-adjustment was “Age recode” (the version with 18 age groups – with 0-4 year olds combined). 5. Fixed bug that showed up when deleting invalid variables on database change. SEER*Stat now preserves variables in the table dimension and retains their order. 6. Fixed bug to prevent updates to the current user profile while a session is executing and the job window is in focus. 7. Updated survival session to calculate relative median survival the first time the cumulative relative estimates reaches 50%. In prior versions, if the relative percentage had reached 50% and then rose to a value above 50% SEER*Stat would not display a median estimate. This is a rare instance that could result in the display of a median relative statistic for a table that previously was shown as can't calculate. 8. The Survival case exclusion checkbox for excluding cases that are Alive With No Survival Time is now unselected and disabled when the Presumed Alive option is selected on the Parameters tab. 9. Re-ordered the controls in the Case Listing Matrix's variable value Find dialog so Field comes before Value. Also handles a problem that could occur if using find in a matrix when no cell has focus. 11/19/2012 - Version 8.0.1 1. Fixed a bug in loading of table variables introduced in version 8.0.0. The order of the variables is now preserved. 11/01/2012 - Version 8.0.0 1. Changed array of session data elements to make arrays dynamic. Users will be warned that sessions saved with this version cannot be opened in older versions of SEER*Stat. 2. Added additional multiple primary selection options to the survival session. This involved adding a new drop-down list box to the bottom of the selection tab and removing the previous checkbox and radio button from within the "Standard Selections" area of the selection tab. 3. Added presumed alive option to survival session. This option assumes that any case not known to be dead will be considered alive on the study cut-off date. 4. Fixed loading of current databases in the data tab to exclude databases without valid ID numbers. Also fixed loading of lists for Expected Rates and Referent rates. 5. Upgraded the resaving of case listings to account for possible change in the size of the session data. 6. Fixed a problem in the calculation of percent progress in the progress dialog, to prevent data overflow. 7. Fixed the function to show Profiles on startup when only one profile exists. 8. Added ability to use delay-adjustment factors in rate/frequency and case listing sessions. Requires database with factors, which are not currently available to research community. In-house beta version only: 9. Several modifications were made to the left-truncated life tables session. 10. Added Pohar-Perme method to survival session. Not feature complete. 7/17/2012 - Version 7.1.0 1. Fixed a problem with the MP-SIR case listing and frequency options that could include cases that were not part of the selected database (e.g. 1975 cases for a 1992-2009 database). This fix did not have any impact on the standard MP-SIR (O/E) calculations. 2. Added a time delay when saving matrix files. In some cases if there was a latency saving the matrix, SEER*Stat would not be able to save and would give an error message stating: "updated by another user". The delay was added to avoid this issue. 3. Added a Server Cache Refresh option to the main menu. 4. Fixed Cum Expected Survival Method to reset to default only when changing to a different database. 5. Fixed initial location of main window to avoid off-screen position saved from a second monitor. 4/12/2012 - Version 7.0.9 1. Added support for Survival calculation by days. 2. Fixed bug in Survival matrix copy with hiding zero count rows. 3. Fixed bug to enable refresh of search statements after editing of invalid statements on database change. 3/5/2012 - Version 7.0.8 1. Age Standardizing added to Survival session as an option. 2. Survival Life Page expanding upgraded, with hiding and showing of zero count rows. 2/16/2012 - Version 7.0.7 1. Fixed changing of categories for Age Variables when more than one age variable is available for Rate and Prevalence sessions. 2. Remove Lost to Follow-Up from Survival session and use Study Cutoff in its place. 3. Fixed MP-SIR session startup to handle database with corrupted cache file. 12/14/2011 - Version 7.0.6 1. Allow invalid user variables to be fixed at session load instead of discarding them. 2. Support multiple Age (for age-adjusting) variables in a single database. 3. Enhanced SAS code generated by matrix export to handle imputed data. 4. Only prompt for software autoupdate from server when installation file is available. 5. Enhanced Survival session verification in client to detect when the number of row cells or column cells exceeds the maximum. 9/1/2011 - Version 7.0.5 1. User Profile export/import now optionally includes user variables. Multiple profiles (and variables) can be exported at once into a single file. 2. Longer variable names and grouping names are now supported. The new max length is 80 chars. 3. Added support on the data tab for a URL for database specific documentation. 4. Fixed matrix export to prevent abort when preserving matrix columns. 5. Fixed handling of hidden databases when a user profile is deleted from the main window menu. 6. Shortened timeouts for various client-server interactions. 3/30/2011 - Version 7.0.4 1. Fixed the default name for a new grouping in the dictionary editor. 2. Changed handling of externally added data locations to prevent auto-adding of multiple server locations. 3. On execute, verify that Prevalence session does not contain the Year of diagnosis field in a merged variable. 4. Fixed handling of scrolling with mouse wheel when viewing a matrix. 3/15/2011 - Version 7.0.3 1. Modified the database hiding tab in the profile dialog to show databases by session type. 2. Fixed check for write access to the temporary files directory before downloading server cache. 3. Added support for external adding of data locations to a profile by SEER*Prep or by the installation program. 2/11/2011 - Version 7.0.2 1. Fixed problem that was not allowing any survival sessions to be opened. 2/02/2011 - Version 7.0.1 1. New functionality was added to the survival session to support database-specific defaults for method for calculating cumulative expected survival. 2. Changed title/numbering of jobs and new matrices to correspond with title of session used to create them. 3. Several issues related to the switch to Microsoft Visual Studio were resolved. 1/20/2011 - Version 7.0.0 1. Changed compilers from Borland C++ builder to Microsoft Visual Studio. Previous builds were incompatible with some installations of Windows. Some users were unable to use SEER*Stat with Windows 7 Ultimate. This change should be transparent with no visual differences. 2. Profiles - The new Profile menu allows you to manage, create and use profiles. A profile stores information about your preferences such as data locations, directories to save files, and matrix export defaults. You can also select which databases you would like to see in SEER*Stat (e.g. you can hide all databases for previous submissions). You can have multiple profiles and switch between them to help organize projects that use different data and possibly different settings. 3. Ederer II was added as the default method for calculating cumulative expected survival. Ederer I had been the default for calculations in previous versions of SEER*Stat. A selection box for Cum Expected Method was added to the survival session's statistics tab to allow you to switch between Ederer II and Ederer I methods. The two options for adjusting for Heterogeneity were also moved from the Output tab to this new selection box. 4. Changes to the edit variable dialog. When you select multiple values and click Add…, you now are prompted to add as a single group or individual values. 5. The term "Limited-Use" was changed to "Research" everywhere in the software. The SEER program had made this change in all database names after the previous release of SEER*Stat, so this is bringing the software in-line with the database names. 6. The MP-SIR calculations were updated in how simultaneous tumors are treated when using early exit criteria. Sequence number is now considered when tumors have the same event dates (date of diagnosis for SIRs). The higher sequence number tumor will not be counted as an event if the lower sequence number was the early exit tumor. 7. A problem was fixed with saving user-defined variables and case listing matrix files. 8. Non-functional previews of future new features were included. This includes the new left-truncated survival session and age-adjustment for survival statistics. 4/1/2010 - Version 6.6.2 1. Removed "rate" from survival statistic references in software and help file. 2. Minor change to resolve problems with auto-update. 3. Minor change to make database verification more efficient when using client-server mode. 2/17/2010 - Version 6.6.1 - Changed the default setting for the Select Only Microscopically Confirmed Standard Case Selection option in the Survival session back to unchecked. The default had inadvertently been changed to checked in version 6.6.0. Any new survival sessions created with version 6.6.0 would have the unintended default value for this option. 1/28/2010 - Version 6.6.0 1. A new standard exclusion checkbox was added to the survival session selection tab for "Alive with no Survival Time". This option is checked by default in all cases. Using the default setting will result in estimates that match any statistics generated with previous versions of SEER*Stat. 2. A new standard exclusion checkbox was added to the survival session for "Dead due to Other Causes with no Survival Time". This checkbox is only available when using a survival measure that uses cause of death rather than expected survival. The default for this checkbox is database specific. All currently available databases have this checkbox checked by default. Using the default setting will result in estimates that match any statistics generated with previous versions of SEER*Stat. 3. New checkbox added to the matrix export dialog for including full path of the input file in generated SAS code. 4. Altered the test used to determine if survival confidence intervals need to be flagged. Test is explained in the SEER*Stat matrix footnote. 5. Fixed autoscroll for variable name in the dictionary edit dialog. 6. Fixed definition of "First Primary Only" in Selection tab for prevalence and MP-SIR sessions. Was excluding prior tumors with sequence numbers of 60+. 7. Analysis options on the MP-SIR session events tab have been modified when using mortality rates as events. Only single outcome analysis is supported, with exit at death. 8. Bug fix for MP-SIR table tab. On database change, if all case listing variables were not valid and user cancelled, original list of variables was duplicated. 9. Bug fix for MP-SIR parameters tab. When invalid cut points were provided for latency or attained calendar years, on database change SEER*Stat would jump to the parameters tab without warning. 10. Fixed a problem with multiple merged variables in a prevalence session. Calculation terminated prematurely when a population field was included in any of the variables. 7/22/2009 - Version 6.5.2 1. Fixed a problem with the survival and MP-SIR session case listing features. The problem would only occur if the first character of the first line of the title was a space. When this occurred the formats for the fields were incorrect. 2. Changes were made to the import variable dialog to not require write access to the file being imported. Wording changes were also made on the dialog. 4/14/2009 - Version 6.5.1 - Production release of 6.5 features. 04/7/2009 - Version 6.5.0-beta 1. Survival session now includes confidence intervals. 2. In the MP-SIR matrix exclusion/inclusion report, corrected a "double counting" of exclusions. 3. A problem that did not allow merged variables to be included in a survival session case listing was corrected. 4. Installation program now created with InstallAware rather than InstallShield. 5. Minor bug fixes and interface improvements. 4/24/2008 - Version 6.4.4 - Bug fixes. 1. In a survival matrix, if changes were made on the matrix options dialog, there was a memory overwrite which often caused SEER*Stat to shutdown and generate an error message. 2. When opening a saved session (including retrieving one from a matrix) and access to the original database is no longer available, the database selection dialog is displayed. Selecting a new database on this dialog did not reset database specific parameters as is done when a user changes the database on the data tab. This has been changed to function like a database change on the data tab. 4/14/2008 - Version 6.4.3 - Production release of 6.4 features. 4/10/2008 - Version 6.4.1-beta - minor fixes 3/31/2008 - Version 6.4.0-beta 1. Bug fix for MP-SIR. The incorrect behavior is that all potential events in the rate file count as observed events, but the expected are calculated correctly (only for those selected), when the following options are chosen. - single outcome - exit on any event in the rate file - uncheck some of the events - don't include the selected event variable in the table 2. For MP-SIR, changed the CI default from approximate to exact. 3. For MP-SIR, changed the default exit point for single outcome analysis from exit on selected events to exit on any event in the rate file. 4. For MP-SIR, added a checkbox for exiting at next malignant tumor which is on by default. 5. SEER*Stat will now calculate an age-adjusted rate when there is a crude age-specific cell with non-zero cases and zero population. 6. SEER*Stat now allows you to calculate period estimates for multiple user-specified years in the same session. Previously it only did the latest possible year. 9/25/2007 - Version 6.3.6 1. Exclude certain variables from case listings with the NoCaseList key in the database.ini. 2. Added descriptions to user-defined variables. 3. Only allow user information to be modified if user is logged in. 4. Fixed page length limit for printing the survival exclusions page. This would hang the print request. 5. No survival Z-test without standard life or relative rate pages. 6. If no referent rates available, allow user to re-create rates from the session. 7. Expected rates in survival are only presented when the base fields match. 8. Added a prompt in the search dialog when there are selected lines and the user tries to paste. 9. Merged variables are now permitted in the selection dialog. They are converted, like user-defined variables, to underlying statements when the OK button is pressed. 10. Negative operators/prefixes are now allowed in merged variables. 11. Added a new line button on the selection dialog 12. SAS code now has lrecl= on the infile statement. 4/12/2007 - Version 6.3.5 - Production release of 6.3 features. 4/5/2007 - Version 6.3.4 - release candidate 3/19/2007 - Version 6.3.3-beta - minor fixes 2/12/2007 - Version 6.3.2-beta - minor fixes 1/23/2007 - Version 6.3.1-beta - minor fixes 1/18/2007 - Version 6.3.0-beta 1. Allow multiple data locations instead of a primary and secondary data location. 2. Changed survival matrix options so that standard errors are handled as a group instead of individual flags for each statistic. This is the same for confidence intervals. 3. Added special selection check boxes for "Malignant Only", "Known Age", "Male/Female Sex" and "Cases in Limited-Use Database" to all session types. 4. The ability to specify categories for use with user-defined variables. 5. Find variable dialog changed to multi-column in order to show matches found in the format separate from those found in the names. 6. Allow import variable definitions from another database to the current database. 7. MP-SIR rates tab: the user can see invalid rate-bases with the reason why they are invalid. 8. MP-SIR rates tab: allow the use of available rate values for cohort values not in rates. 9. Rate session: Tiwari method for confidence intervals. 10. Frequency or rate matrix export: added feature to preserve matrix columns and rename variables. 11. Survival statistic tab: missing/unknown CODs are included as dead broken out between specified cause and other causes. 8/31/2006 - Version 6.2.4 1. There was an error in the prevalence session if you made a selection using a linked variable (a county attribute). This was only a problem in the selections (not the table or cohort tabs). It gave an error and didn't complete; there were no incorrect calculations. 2. A fix to survival for excluding cases with unknown COD. SEER*Stat was excluding even when the death was after study cut-off. Since SEER's COD variables use study cut-off date, most analyses on SEER's data would be fine. But if the user changed the study cut-off date, or analyzed a user created database without recoding the deaths after study cut-off to alive, this would affect the results. 3. A fix to survival for handling unknown/missing CODs in crude probability of death analyses. There are three options: exclude, include as dead, include as censored. The include as censored option was incorrectly including cases as dead due to other causes. This has been changed to include these as lost to follow-up. We're planning to add a fourth option to allow the user to include them as dead due to other causes in a future release. 4. Matrix export allows the creation of SAS code. 5. Performance enhancements in the dictionary editor for the State-county variable. 6. The MP-SIR session now supports databases with different variable for start and event dates. Previous versions only supported date of cancer diagnosis for both of these dates. 4/5/2006 - Version 6.2.3 - Fix a problem which caused an MP-SIR session to close if the first database listed didn't have referent rates. 3/29/2006 - Version 6.2.2 1. Change to selection dialog to not accept some invalid characters. 2. Change to not allow matrix save, print, options, etc. if while the matrix is open, it changes on disk. The change could be by another person or by the same person having multiple copies open. 3. Reload primary and secondary database.ini files in more situations. 4. Fix to present database citation and database message if a user-supplied database is listed first. 1/19/2006 - Version 6.2.1 - Set maximum p-value of rate ratios to 1.0 and other minor fixes. 11/22/2005 - Version 6.2.0-beta 1. More graceful handling of lost network connectivity. 2. Go to page number in print preview. 3. Support for large fonts. 4. Password can optionally be remembered. 5. Ability to display a login message obtained from the server. 6. A Primary Data Location (PDL) is no longer required. 7. The PDL and Secondary Data Location (SDL) can be interchanged. 8. Faster loading of sessions when executing in local mode. 9. Referent rates are downloaded separate and thus less often from the other database materials. 10. Client-server menu items are more prominent. 11. New preferences dialog to more clearly distinguish between local and client-server mode, and to more clearly distinguish the port for client-server mode. 12. Faster writing and exporting a matrix to a network location. 13. New database.ini options for disabling the case listing functionality in Survival and MP-SIR sessions. 14. Improved Data tab in order to more easily distinguish which databases have linked (SES) data. 4/14/2005 - Version 6.1.4 - More minor improvements and revised help. Disabled profile survival method for limited-duration prevalence. 4/1/2005 - Version 6.1.3-beta - More minor interface and output improvements. 3/24/2005 - Version 6.1.2-beta - Minor interface and output improvements. New help system. 3/17/2005 - Version 6.1.1-beta - Updates to median survival, standard errors, and the Z-test for Kaplan-Meier survival. Minor interface fixes. 3/10/2005 - Version 6.1.0-beta 1. Prevalence and rate sessions - statistics can be hidden based on population size (existing feature based on count remains). 2. Prevalence, rate, and frequency sessions - when statistics are hidden based on counts, there is no suppression for 0, only if > 0 and less than the specified number. 3. MP-SIR session - exact CIs (existing approximate CIs remain). 4. Rate ratios for significance testing in the rate session. 5. Profile survival method for limited-duration prevalence. 6. Survival session: a. Kaplan-Meier survival (actuarial is still the default) b. New defaults: - 1 month intervals - number of intervals changed from 5 to 60 (still 5 years) - cumulative summary tables on - standard life tables off c. Option to include a "0th interval" d. Special intervals (conditional survival) can be included in cumulative summary tables e. Special intervals (conditional survival) are available for all cumulative statistics f. Matrix options dialog allows hiding statistics in cumulative summary tables g. Dimension of variables can be specified in the cumulative summary tables h. New dialog for defining intervals of cumulative summary tables i. Moved the display section from the output tab to the parameters tab j. Period survival for all survival session methods. 7. Save session as an "ini" text file. 8. Improvements to print preview that make it easier to navigate to the beginning, end, or specified page of a document. 10/18/2004 - Version 5.3.1 1. Fixed error in prevalence session when selecting on age at prevalence. This error was introduced in version 5.3.0. This does not affect analyses with age at prevalence in the table definition. 2. Fixed error in prevalence session survival calculations when the survival cohort variables do not include values for all records included in an analysis. 8/16/2004 - Version 5.3.0 1. Ability for a single server to handle both encrypted and non-encrypted communications. 2. Session printout as text. 3. Survival now defaults to displaying percents. 4. Merged variables now store numeric variable values in the session and user-defined format libraries in addition to labels. 5. New help system. 6. Prevalence can now be calculated by months prior instead of only supporting years. 7. Blanks are now removed from MP-SIR parameters before verifying. 8. Fixes for related variables in MP-SIR and person selection features of other sessions. 9. Exclude population defining variables that can change for a person (e.g. county) from use in defining referent rates. Also exclude related variables based on these variables. 10. Always check user-defined variables in search statements on database change. 11. Session printout now has title. 12. Fixed problem in survival matrix export when multiple page types are present. Specifically, some export dialog options were not used correctly for all page types. 4/12/2004 - Version 5.2.2 - Minor fixes to client-server communications. 4/8/2004 - Version 5.2.1-beta - Corrected a problem with status updates in client-server mode for the prevalence session, and a printing problem for databases without a suggested citation if working client-server mode and the local database cache is not available. 4/6/2004 - Version 5.2.0-beta - Encrypted communications between the client and server. 1/15/2004 - Version 5.1.14 - Minor fixes to MP-SIR. 1/13/2004 - Version 5.1.13 - Addition of the Select Only Malignant Behavior check box to the frequency, rate, and case listing sessions. Minor bug fixes and additional options for ssexport under UNIX. 1/7/2004 - Version 5.1.12 - Within MP-SIR, the computations of both "Mean Date of Exposure" and "Mean Date of Event" were updated to correct a problem of these dates being exactly one year early. 12/19/2003 - Version 5.1.11-beta - Minor fixes. 12/17/2003 - Version 5.1.10-beta - First public release. 12/15/2003 - Version 5.1.9-beta - Updates to MP-SIR and help. 12/5/2003 - Version 5.1.8-beta - Updates to MP-SIR. 12/2/2003 - Version 5.1.7-beta - Updates to MP-SIR. 12/1/2003 - Version 5.1.6-beta - Updates to MP-SIR. 11/24/2003 - Version 5.1.5-beta - Updates to MP-SIR and help. 11/21/2003 - Version 5.1.4-beta - Updates to MP-SIR and help. 11/20/2003 - Version 5.1.3-beta - Updates to MP-SIR. 11/18/2003 - Version 5.1.2-beta - Updates to MP-SIR. 11/12/2003 - Version 5.1.1-beta - Feature complete version of MP-SIR and new selection dialog. 9/16/2003 - Version 5.1.0-beta - Nearing a feature complete version of MP-SIR. 9/16/2003 - Version 5.0.20 - Client now attempts a connection to PDL seerstat.imsweb.com if seerstat.cancer.gov fails. 8/21/2003 - Version 5.0.19 - Modified selection dialog to allow work with both continuous and discrete values of a variable. 7/21/2003 - Version 5.0.18 - Several minor updates to wording and presentation to make things clearer and cleaner in the interface and help system. Added functionality post a variable specific warning dialog. Several other minor updates to functionality. 4/25/2003 - Version 5.0.17 - Updates to code associated with the standard population control on the statistic tab of the rate and prevalence sessions. 4/23/2003 - Version 5.0.16 - Updates to help. 4/15/2003 - Version 5.0.15 - Updates to help. 4/11/2003 - Version 5.0.14-beta - Updates to prevalence and inclusion of new help. 4/4/2003 - Version 5.0.13-beta - Updates to prevalence and MP-SIR. 3/26/2003 - Version 5.0.12-beta - Inclusion of suggested citations. 3/24/2003 - Version 5.0.11-beta - Updates to MP-SIR. 3/20/2003 - Version 5.0.10-beta - Updates to prevalence and MP-SIR. 3/17/2003 - Version 5.0.9-beta - Updates to prevalence and MP-SIR. 3/12/2003 - Version 5.0.8-beta - Updates to prevalence and MP-SIR. 2/21/2003 - Version 5.0.7-beta - Wider release of the beta product. 2/19/2003 - Version 5.0.6-beta - Minor fixes. 2/14/2003 - Version 5.0.5-beta - Updates to prevalence and MP-SIR. 2/5/2003 - Version 5.0.4-beta - Updates to MP-SIR. 2/3/2003 - Version 5.0.3-beta - Updates to MP-SIR. 1/31/2003 - Version 5.0.2-beta - Updates to MP-SIR. 1/28/2003 - Version 5.0.1-beta - Updates to prevalence and MP-SIR. 1/3/2003 - Version 5.0.0-beta - Initial release with prevalence and MP-SIR. 10/29/2002 - Version 4.2.7 - Minor fixes to the following. 1. When merged variable base names exceeded 200 characters. 2. Divide by zero situation in the calculation of APCs. 3. Export dictionary when variables were reordered in the matrix. 6/6/2002 - Version 4.2.6 - Performance enhancements to the relational model that gracefully merges socio-economic data with the cases and populations for the generation of rates. 5/20/2002 - Version 4.2.4 - Minor fixes and the ability to disable trends in the frequency session. Also, the ability to independently specify whether a database should be presented in a frequency and/or rate session. 4/3/2002 - Version 4.2.3 - Minor fixes. 3/21/2002 - Version 4.2.2-Beta - Minor fixes and the auto-update feature. 3/7/2002 - Version 4.2.1-Beta 1. Relational model to gracefully merge socio-economic data with the cases and populations for the generation of rates. 2. New client-server security model that uses groups to maintain user permissions. 3. Checksum of user's local cache prior to client-server execution. 4. Redesign of communication protocol for canceling a client-server analysis. 5. Improvements to find variable functionality. 6. Functionality to search for a value in a case listing matrix. 7. Certain dialogs are now sizeable. 8. Use of new common file dialog in Windows 2000 and XP. 9. Ability to specify a path for storing temporary files. 10. Printing enhancements. 11. Ability to cancel a database change. 12. "Tree view" on frequency and rate table tab. 13. User generated standard populations and expected rates are uploaded to the server for temporary use during calculations. 14. If a database doesn't exist on session open, the user can now specify which database should be utilized (or attempted). 11/4/2001 - Version 4.1.4 - Set AA rates to default statistic in rate session; minor bug fixes when switching between databases with different age variables and standard populations; functionality to specify default for PC end points in the database.ini. 10/16/2001 - Version 4.1.3 - Several bug fixes including a correction to problems with exporting a case listing matrix. Added support to allow use of standard populations with other than 18 age groups. SEER*Prep 1.8+ is a requirement if processing user-supplied standard populations. 6/28/2001 - Version 4.1.2-Beta - Corrected problem with ZD sorting. 6/12/2001 - Version 4.1.1-Beta - Corrected problem of frequencies being three times too large for population only databases. 5/24/2001 - Version 4.1.0-Beta - Split of the frequency/rate session into two separate entities. 4/2/2001 - Version 4.0.9 - Bug fix for ZD sort not initializing cache size properly. 3/30/2001 - Version 4.0.8 - Bug fixes. 3/29/2001 - Version 4.0.7 - Bug fixes. 3/28/2001 - Version 4.0.6 - UNIX matherr handler. 3/27/2001 - Version 4.0.5 - Bug fixes. 3/26/2001 - Version 4.0.4 - Bug fixes. 3/19/2001 - Version 4.0.3 - Bug fixes. 2/22/2001 - Version 4.0.2-beta - Generalization of variables included in the expected rate tables to support SEER*Prep 2.0, bug fixes, numerous minor enhancements, the ability mask out specified values of the COD variables when they are displayed in the controls for cause-specific survival, and the ability to filter statistics with a decimal point in the case listing matrix. 1/8/2001 - Version 4.0.1-beta - HTML help, bug fixes, and numerous minor enhancements. 10/10/2000 - Version 4.0.0-beta - Multiple primary selection features in freq/rate and case listing, cause specific survival, weighted least squares estimates for APCs, PCs with single year end-points, case listing output from survival including the cumulative expected rate, printing enhancements, and general interface refinements. 2/16/2001 - Version 3.0.11 - ZD bug fix for checking set size needed for compatibility with SEER*Prep 1.5+. 9/13/2000 - Version 3.0.10 - Support for MinimumVersion= key in the database.ini. 8/28/2000 - Version 3.0.9 - Use of ZD's operator precedence, support for ICD-10 as a continuous variable, fixes to merged variables when based on a user-defined, and other bug fixes. 3/27/2000 - Version 3.0.8 - Minor bug fixes over first release candidate. 3/23/2000 - Version 3.0.7 - First release candidate of "Version 3.0". 3/3/2000 - Version 3.0.5-beta - Export enhancements, conversion of the export dictionary to an ".ini file", and support for user-supplied standard millions. 2/10/2000 - Version 3.0.0-beta - Initial release of the case listing session, enhancements to merged variables, adjustments for heterogeneity in withdrawal (Hakulinen adjustments) for relative survival, and an option for user-defined variable definitions in the session printout. 11/17/1999 - Version 2.1.5 - Fixes for icon problems noticeable in earlier versions of 2.1. Fixes for problems downloading the database files file from the server under Windows 9x. 10/22/1999 - Version 2.1.4 - Fix to allow merged variables based on non-indexed variables. 10/6/1999 - Version 2.1.3 - Minor bug fixes and further performance improvements for subsetting non-indexed variables. 9/16/1999 - Version 2.1.2-beta - Improved performance for subsetting on non-indexed variables. 9/14/1999 - Version 2.1.1-beta - Version checking between the client and server, support for user-supplied expected rates, import/export of user-defined variables, support for the Census tract variable, the ability to hide PCs and APCs independently, and support for session printouts that exceed one piece of paper. 7/16/1999 - Version 2.1 (Beta 2) - Client-server, hyperlinks in variable descriptions, and minimize on modal status dialog. 7/7/1999 - Version 2.1 (Beta 1) - Borland C++ Builder 4 and variable merging. Beginnings of Hakulinen adjustments and crude survival. 3/30/1999 - Version 2.0 - Minor fixes over Beta 1. 1/22/1999 - Version 2.0 (Beta 1) - General interface refinements and minor fixes. Tighter integration with SEER*Prep. Migration to Borland C++ Builder. Refinements to allow easier maintenance of network installations. Compilation of calculation module under Solaris. August 1998 submission of SEER, 1973-1996 diagnoses. 7/21/1998 - Version 1.1.2 - Bug fix in subset for "short" variables with values exceeding 32k. Needed for State/county variable. 7/9/1998 - Version 1.1.1 - Support for multiple types of summary files. That is, different variables in each type. 8/11/1998 - Version 1.1a - Functionality to support 1991 Canadian standard millions. 4/3/1998 - Version 1.1 - General interface refinements and minor fixes. August 1997 submission of SEER, 1973-1995 diagnoses. 10/15/1997 - Version 1.0 - Printing and footnote enhancements. Help system and general interface refinements. August 1996 submission of SEER, 1973-1994 diagnoses. 8/13/1997 - Version 1.0 (Beta 2) - Survival calculations and enhancements to incidence calculations. User-defined variables are "memory based" by default and optionally saved to disk. August 1996 submission of SEER, 1973-1994 diagnoses. 3/7/1997 - Beta Version 1.0 - Initial release including incidence calculations. February 1996 submission of SEER, 1973-1993 diagnoses. ----------------- TECHNICAL SUPPORT ----------------- Email: email@example.com Web: www.seer.cancer.gov/seerstat